HitPredict

Interactor 1: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Interactor 2: WASP (P42768)
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)
Gene: WAS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14521508
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras
Common GO terms	GO:0005884 - actin filament GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 502
+	Hs
		126960 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		WASL_HUMAN (15-311): 1.14e-115: 352: 47.67
+	Hs
		790687 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		WASP_HUMAN (1-487): 8.09e-99: 308: 100.00
+	Hs
		126910 RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00		WASL_HUMAN (15-311): 1.14e-115: 352: 47.67
+	Hs
		126927 CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57		WASL_HUMAN (15-311): 1.14e-115: 352: 47.67
+	Hs
		790658 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		WASP_HUMAN (1-487): 8.09e-99: 308: 100.00
+	Hs
		790653 CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57		WASP_HUMAN (1-487): 8.09e-99: 308: 100.00
+	Hs
		545246 RAC2_HUMAN (10-196): 1.67e-76: 229: 62.03		WASP_HUMAN (1-487): 8.09e-99: 308: 100.00
+	Dm
		776909 RAC1_DROME (10-195): 1.67e-76: 229: 63.98		Q9VAT0_DROME (13-324): 3.69e-84: 271: 35.98
+	Ce
		983032 CDC42_CAEEL (10-193): 3.51e-91: 266: 67.94		Q17795_CAEEL (13-498): 3.91e-60: 209: 21.66
+	Ce
		975571 RAC1_CAEEL (10-204): 4.48e-78: 233: 57.44		Q17795_CAEEL (13-498): 3.91e-60: 209: 21.66
+	Ce
		104465 G5EBV3_CAEEL (1-204): 1.7e-75: 227: 49.51		Q17795_CAEEL (13-498): 3.91e-60: 209: 21.66
+	Hs
		297840 RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11
+	Sc
		580329 CDC42_YEAST (10-185): 5.8e-85: 251: 66.48		STE20_YEAST (152-471): 7.83e-21: 98.2: 14.84
+	Hs
		840659 RHOA_HUMAN (1-201): 1.3e-76: 230: 49.75		DYN2_HUMAN (244-438): 9.39e-25: 110: 17.54
+	Hs
		297827 RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11
+	Hs
		297823 RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11
+	Hs
		195972 RHOA_HUMAN (1-201): 1.3e-76: 230: 49.75		PLXB1_HUMAN (307-500): 2.97e-12: 71.5: 23.50
+	Hs
		297820 RHOA_HUMAN (1-201): 1.3e-76: 230: 49.75		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11
+	Hs
		297812 RAC2_HUMAN (10-196): 1.67e-76: 229: 62.03		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11
+	Hs
		297822 RHOB_HUMAN (1-204): 1.77e-75: 227: 49.51		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11