Protein: SEPT6
Septin-6

Gene: SEPT6, SEPTIN6
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q14141

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0000776 - kinetochore
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005819 - spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1121177

SEPT2
Septin-2

13

19

Small-scale

0.984

High

1121181

SEPT7
Septin-7

13

19

Small-scale

0.980

High

1121205

SEPT9
Septin-9

10

19

Small-scale

0.977

High

1121195

SEPT5
Septin-5

7

19

Small-scale

0.973

High

1121190

SEPT1
Septin-1

7

19

High-throughput

0.971

High

1121186

SEP12
Septin-12

6

19

Small-scale

0.950

High

1121204

SEPT3
Neuronal-specific septin-3

6

19

High-throughput

0.948

High

1121201

SEP11
Septin-11

5

19

High-throughput

0.925

High

1121202

SEP10
Septin-10

5

19

High-throughput

0.919

High

1121191

SEPT8
Septin-8

4

20

High-throughput

0.903

High

210493

SEPT4
Septin-4

3

20

High-throughput

0.861

High

1121184

SEP14
Septin-14

3

19

High-throughput

0.861

High

1121197

BORG4
Cdc42 effector protein 4

4

15

High-throughput

0.691

High

529777

TAU
Microtubule-associated protein tau

2

15

High-throughput

0.628

High

1121187

MORN4
MORN repeat-containing protein 4

3

2

High-throughput

0.616

High

1121200

ANLN
Anillin

2

12

High-throughput

0.611

High

911832

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

3

3

High-throughput

0.609

High

1093352

TRI32
E3 ubiquitin-protein ligase TRIM32

3

4

High-throughput

0.609

High

3514

A0A0S2Z5W9
Septin 9 isoform 3

1

20

High-throughput

0.590

High

375509

RASK
GTPase KRas

2

20

High-throughput

0.584

High

914607

RM12
Large ribosomal subunit protein bL12m

2

9

High-throughput

0.574

High

1121193

SH3K1
SH3 domain-containing kinase-binding protein 1

2

7

Small-scale

0.543

High

535049

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.536

High

855619

CRK
Adapter molecule crk

2

8

High-throughput

0.526

High

1121199

PKHF2
Pleckstrin homology domain-containing family F member 2

1

6

High-throughput

0.523

High

404049

GCR
Glucocorticoid receptor

1

12

High-throughput

0.515

High

966300

1433G
14-3-3 protein gamma

1

1

High-throughput

0.515

High

1121192

KAT5
Histone acetyltransferase KAT5

1

1

High-throughput

0.515

High

155158

SOCS7
Suppressor of cytokine signaling 7

1

2

Small-scale

0.506

High

158725

BORG1
Cdc42 effector protein 2

1

15

Small-scale

0.501

High

1121185

RHOU
Rho-related GTP-binding protein RhoU

1

13

High-throughput

0.501

High

720216

UFO
Tyrosine-protein kinase receptor UFO

1

20

High-throughput

0.500

High

127080

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.493

High

642549

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.493

High

485136

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

Small-scale

0.489

High

773495

COPB2
Coatomer subunit beta'

1

9

High-throughput

0.489

High

1121194

ACAP3
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

1

10

High-throughput

0.489

High

172803

XPO1
Exportin-1

1

13

High-throughput

0.479

High

210566

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

2

High-throughput

0.479

High

373926

RASN
GTPase NRas

1

20

High-throughput

0.479

High

374595

RASH
GTPase HRas

1

19

High-throughput

0.479

High

540449

LAMP1
Lysosome-associated membrane glycoprotein 1

1

4

High-throughput

0.479

High

898460

PPT1
Palmitoyl-protein thioesterase 1

1

1

High-throughput

0.479

High

955154

CDC42
Cell division control protein 42 homolog

1

13

High-throughput

0.479

High

1121175

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.479

High

603267

KPCA
Protein kinase C alpha type

1

1

High-throughput

0.470

High

843554

HD
Huntingtin

1

8

High-throughput

0.470

High

1121178

SETB1
Histone-lysine N-methyltransferase SETDB1

1

4

High-throughput

0.470

High

1121196

NSD3
Histone-lysine N-methyltransferase NSD3

1

5

High-throughput

0.464

High

1121176

CUL7
Cullin-7

1

0

High-throughput

0.458

High

1121206

BORG2
Cdc42 effector protein 3

1

15

Small-scale

0.457

High

255017

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.445

High

890649

RGS3
Regulator of G-protein signaling 3

1

9

High-throughput

0.445

High

1121198

VIAAT
Vesicular inhibitory amino acid transporter

1

4

High-throughput

0.445

High

105916

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

241649

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.437

High

353321

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.437

High

363272

EGFR
Epidermal growth factor receptor

1

17

High-throughput

0.437

High

410836

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

19

High-throughput

0.437

High

465516

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.437

High

484139

PGFRB
Platelet-derived growth factor receptor beta

1

18

High-throughput

0.437

High

541480

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.437

High

563745

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.437

High

582787

EZRI
Ezrin

1

3

High-throughput

0.437

High

623339

RO52
E3 ubiquitin-protein ligase TRIM21

1

2

High-throughput

0.437

High

648508

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.437

High

695427

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

710830

EPHB2
Ephrin type-B receptor 2

1

14

High-throughput

0.437

High

768160

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

838091

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

High-throughput

0.437

High

931850

EPHA5
Ephrin type-A receptor 5

1

16

High-throughput

0.437

High

1024570

VIGLN
Vigilin

1

1

High-throughput

0.437

High

1067311

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.437

High

1121179

EPHA7
Ephrin type-A receptor 7

1

11

High-throughput

0.437

High

1121180

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.437

High

1121182

VIR
Protein virilizer homolog

1

4

High-throughput

0.437

High

1121183

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

1121189

BICD2
Protein bicaudal D homolog 2

1

7

High-throughput

0.437

High

1121203

CEP72
Centrosomal protein of 72 kDa

1

1

High-throughput

0.437

High

1121207

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

839008

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.407

High

934593

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.407

High

886848

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.373

High

1013296

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

301420

WFS1
Wolframin

1

0

High-throughput

0.268

Low

642226

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.268

Low

705332

GRN
Progranulin

1

0

High-throughput

0.268

Low

1121188

LMO3
LIM domain only protein 3

1

0

High-throughput

0.268

Low

246594

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.265

Low

405456

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.265

Low

134731

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.249

Low

443062

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.249

Low

613032

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025