HitPredict

Interactor 1: ZNF8 (P17098)
Zinc finger protein 8 (Zinc finger protein HF.18)
Gene: ZNF8

Interactor 2: CBX3 (Q13185)
Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Gene: CBX3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	34079125, 21888893, 31403225
Identification Methods	proximity labelling technology, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 575 Hs			1 183
+	Hs
		565107 ZNF8_HUMAN (1-575): 0: 750: 100.00		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		200243 ZN264_HUMAN (12-574): 0: 636: 29.14		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		1027123 ZN283_HUMAN (67-567): 0: 573: 29.94		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027128 ZN565_HUMAN (3-569): 0: 560: 34.86		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		316190 ZN624_HUMAN (67-550): 0: 612: 27.91		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78
+	Hs
		67855 ZN724_HUMAN (68-426): 9.34e-149: 443: 33.43		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		728565 ZNF93_HUMAN (283-574): 3.56e-123: 377: 32.53		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027188 ZN479_HUMAN (252-570): 1.56e-116: 357: 37.62		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027150 ZN480_HUMAN (294-568): 1.8e-108: 337: 36.73		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		800355 ZN543_HUMAN (313-574): 9.56e-122: 373: 32.82		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		800493 ZN479_HUMAN (252-570): 1.56e-116: 357: 37.62		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		1026996 ZN460_HUMAN (19-565): 8e-91: 291: 34.40		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		800376 ZN460_HUMAN (19-565): 8e-91: 291: 34.40		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		563302 ZNF16_HUMAN (337-574): 9.45e-63: 220: 24.37		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		1027143 ZN420_HUMAN (406-574): 6.61e-60: 212: 23.67		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		599068 ZNF10_HUMAN (197-425): 1.55e-55: 198: 42.80		CBX3_HUMAN (1-183): 1.62e-71: 215: 100.00
+	Hs
		64158 ZN726_HUMAN (372-574): 1.11e-64: 224: 23.79		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		58857 A2VDJ6_HUMAN (214-425): 1.84e-63: 218: 50.00		CBX5_HUMAN (11-182): 1.62e-55: 175: 59.89
+	Hs
		316165 Z286A_HUMAN (247-552): 4.64e-57: 201: 37.79		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78
+	Hs
		316017 ZNF92_HUMAN (428-573): 1.48e-46: 174: 19.18		CBX6_HUMAN (21-124): 3.3e-27: 107: 27.78