HitPredict

Interactor 1: INAR1 (P17181)
Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1)
Gene: IFNAR1

Interactor 2: INAR2 (P48551)
Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)
Gene: IFNAR2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

The method score is based on:

Property	Details
Experiments	24075985, 8969169, 21854986
Identification Methods	affinity chromatography technology, coimmunoprecipitation, x-ray crystallography
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Interfer-bind~Interfer-bind, Interfer-bind~Tissue_fac, Tissue_fac~Tissue_fac
Common GO terms	GO:0004905 - type I interferon receptor activity GO:0005886 - plasma membrane GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0008269 - JAK pathway signal transduction adaptor activity GO:0009615 - response to virus and 5 others more... GO:0019955 - cytokine binding GO:0019962 - type I interferon binding GO:0035458 - cellular response to interferon-beta GO:0060337 - type I interferon-mediated signaling pathway GO:0098586 - cellular response to virus
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	557
Hs

1	515

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024