Protein: PCGF6
Polycomb group RING finger protein 6 (Mel18 and Bmi1-like RING finger) (RING finger protein 134)

Gene: PCGF6
Organism: Homo sapiens
Interactions: 194
UniProt ID: Q9BYE7

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006338 - chromatin remodeling
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1404738

RING2
E3 ubiquitin-protein ligase RING2

12

20

Small-scale

0.982

High

1055851

RING1
E3 ubiquitin-protein ligase RING1

8

19

Small-scale

0.973

High

1326075

RYBP
RING1 and YY1-binding protein

8

20

High-throughput

0.970

High

351403

CBX7
Chromobox protein homolog 7

6

20

Small-scale

0.956

High

1314048

YAF2
YY1-associated factor 2

6

20

High-throughput

0.945

High

1418399

CBX8
Chromobox protein homolog 8

5

20

High-throughput

0.939

High

129801

CBX4
E3 SUMO-protein ligase CBX4

4

20

High-throughput

0.909

High

1204635

BCORL
BCL-6 corepressor-like protein 1

3

19

High-throughput

0.861

High

765856

BMI1
Polycomb complex protein BMI-1

2

19

Small-scale

0.757

High

998769

H31
Histone H3.1

2

19

High-throughput

0.754

High

1380958

LMBL2
Lethal(3)malignant brain tumor-like protein 2

7

20

Small-scale

0.751

High

282776

E2F6
Transcription factor E2F6

7

15

Small-scale

0.746

High

959649

MAX
Protein max

7

16

Small-scale

0.746

High

965215

WDR5
WD repeat-containing protein 5

6

17

High-throughput

0.736

High

1097541

CBX3
Chromobox protein homolog 3

6

20

Small-scale

0.736

High

1310124

MGAP
MAX gene-associated protein

6

14

High-throughput

0.733

High

1014193

CBX1
Chromobox protein homolog 1

5

20

High-throughput

0.722

High

1122863

TFDP1
Transcription factor Dp-1

5

5

High-throughput

0.722

High

1361277

AUTS2
Autism susceptibility gene 2 protein

5

20

Small-scale

0.720

High

1110049

HDAC1
Histone deacetylase 1

5

10

High-throughput

0.716

High

625600

CSK22
Casein kinase II subunit alpha'

4

20

High-throughput

0.699

High

1122893

TFDP2
Transcription factor Dp-2

4

5

High-throughput

0.699

High

253566

PEX10
Peroxisome biogenesis factor 10

1

9

High-throughput

0.698

High

373073

MYC
Myc proto-oncogene protein

4

20

Small-scale

0.692

High

997997

CSK21
Casein kinase II subunit alpha

3

20

High-throughput

0.675

High

1368098

HDAC2
Histone deacetylase 2

3

10

High-throughput

0.675

High

960548

PSME3
Proteasome activator complex subunit 3

3

2

High-throughput

0.667

High

1324712

MIER2
Mesoderm induction early response protein 2

3

6

High-throughput

0.667

High

1418403

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.663

High

1353418

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

3

20

High-throughput

0.662

High

1418398

FBRS
Probable fibrosin-1

5

20

High-throughput

0.654

High

338951

CBX6
Chromobox protein homolog 6

1

20

High-throughput

0.647

High

957185

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

1418388

PCGF6
Polycomb group RING finger protein 6

1

19

Small-scale

0.647

High

1233902

WBP2L
Postacrosomal sheath WW domain-binding protein

3

0

High-throughput

0.638

High

1371658

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

20

High-throughput

0.628

High

1418393

ZN644
Zinc finger protein 644

2

4

High-throughput

0.628

High

1218755

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

766117

PCGF2
Polycomb group RING finger protein 2

1

19

High-throughput

0.618

High

971037

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.618

High

1017185

H33
Histone H3.3

1

19

High-throughput

0.618

High

1132233

CBX2
Chromobox protein homolog 2

1

20

High-throughput

0.618

High

1185943

PCGF3
Polycomb group RING finger protein 3

1

19

High-throughput

0.618

High

1250652

BCOR
BCL-6 corepressor

1

20

High-throughput

0.618

High

1286263

PCGF5
Polycomb group RING finger protein 5

1

19

High-throughput

0.618

High

1412809

PCGF1
Polycomb group RING finger protein 1

1

19

High-throughput

0.618

High

1418415

CARD8
Caspase recruitment domain-containing protein 8

2

0

High-throughput

0.602

High

1154290

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

High-throughput

0.575

High

1418394

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

20

High-throughput

0.575

High

1246429

CORO6
Coronin-6

2

14

High-throughput

0.574

High

848170

MAGA1
Melanoma-associated antigen 1

1

9

Small-scale

0.552

High

274049

CREST
Calcium-responsive transactivator

1

5

High-throughput

0.541

High

279480

TULP3
Tubby-related protein 3

1

1

High-throughput

0.541

High

423699

ARGI1
Arginase-1

1

4

High-throughput

0.536

High

659582

CRCM
Colorectal mutant cancer protein

1

4

High-throughput

0.536

High

853396

CBX5
Chromobox protein homolog 5

1

20

High-throughput

0.536

High

899565

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.536

High

921057

FOSB
Protein FosB

1

15

High-throughput

0.536

High

964732

DCAF7
DDB1- and CUL4-associated factor 7

1

20

High-throughput

0.536

High

995244

CSK2B
Casein kinase II subunit beta

1

9

High-throughput

0.536

High

1100341

TIF1B
Transcription intermediary factor 1-beta

1

20

High-throughput

0.536

High

1156324

HSPB2
Heat shock protein beta-2

1

5

High-throughput

0.536

High

1353593

ZN526
Zinc finger protein 526

1

1

High-throughput

0.536

High

1382524

TRI52
E3 ubiquitin-protein ligase TRIM52

1

19

High-throughput

0.536

High

1418419

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

2

High-throughput

0.536

High

1162032

H31T
Histone H3.1t

1

19

High-throughput

0.527

High

1233791

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.513

High

185990

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

9

High-throughput

0.501

High

238745

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

2

High-throughput

0.489

High

391446

FRIL
Ferritin light chain

1

1

High-throughput

0.489

High

610871

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.489

High

821551

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.489

High

876158

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.489

High

882139

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.489

High

899213

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.489

High

1007254

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.489

High

1323704

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

5

High-throughput

0.489

High

1407551

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.489

High

1409641

DHB14
L-fucose dehydrogenase

1

4

High-throughput

0.489

High

1418400

FBSL
Fibrosin-1-like protein

1

20

High-throughput

0.489

High

288504

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

20

High-throughput

0.481

High

1121327

TRI14
Tripartite motif-containing protein 14

1

18

High-throughput

0.481

High

1350836

MAGE2
Melanoma-associated antigen E2

1

9

Small-scale

0.481

High

1380842

TRI63
E3 ubiquitin-protein ligase TRIM63

1

19

High-throughput

0.481

High

1418389

TRI55
Tripartite motif-containing protein 55

1

19

High-throughput

0.481

High

1418411

MAGC2
Melanoma-associated antigen C2

1

9

Small-scale

0.481

High

1418414

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

15

High-throughput

0.481

High

127177

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.479

High

143469

E2F3
Transcription factor E2F3

1

15

High-throughput

0.479

High

210110

CRX
Cone-rod homeobox protein

1

18

High-throughput

0.479

High

285455

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

339845

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

349233

LATS1
Serine/threonine-protein kinase LATS1

1

8

High-throughput

0.479

High

442803

RB
Retinoblastoma-associated protein

1

2

High-throughput

0.479

High

461895

HS90A
Heat shock protein HSP 90-alpha

1

13

High-throughput

0.479

High

468764

HS90B
Heat shock protein HSP 90-beta

1

14

High-throughput

0.479

High

519419

MYB
Transcriptional activator Myb

1

4

High-throughput

0.479

High

538465

EGR2
E3 SUMO-protein ligase EGR2

1

7

High-throughput

0.479

High

600441

ZKSC1
Zinc finger protein with KRAB and SCAN domains 1

1

4

High-throughput

0.479

High

675657

TYY1
Transcriptional repressor protein YY1

1

16

High-throughput

0.479

High

679250

DNJB1
DnaJ homolog subfamily B member 1

1

4

High-throughput

0.479

High

685337

PAX6
Paired box protein Pax-6

1

16

High-throughput

0.479

High

739025

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

837086

ELK3
ETS domain-containing protein Elk-3

1

19

High-throughput

0.479

High

897386

CDK7
Cyclin-dependent kinase 7

1

8

High-throughput

0.479

High

944733

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

980273

H4
Histone H4

1

7

High-throughput

0.479

High

992322

SKP1
S-phase kinase-associated protein 1

1

11

High-throughput

0.479

High

1006873

PHC1
Polyhomeotic-like protein 1

1

20

High-throughput

0.479

High

1029149

E2F1
Transcription factor E2F1

1

15

High-throughput

0.479

High

1037892

HEN1
Helix-loop-helix protein 1

1

2

High-throughput

0.479

High

1045727

TF65
Transcription factor p65

1

5

High-throughput

0.479

High

1050750

MAD1
Max dimerization protein 1

1

17

Small-scale

0.479

High

1094728

CAF1A
Chromatin assembly factor 1 subunit A

1

8

High-throughput

0.479

High

1094807

CAF1B
Chromatin assembly factor 1 subunit B

1

12

High-throughput

0.479

High

1124154

E2F2
Transcription factor E2F2

1

15

High-throughput

0.479

High

1132951

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

High-throughput

0.479

High

1146297

E2F5
Transcription factor E2F5

1

15

High-throughput

0.479

High

1156850

E2F4
Transcription factor E2F4

1

15

High-throughput

0.479

High

1161647

IF16
Gamma-interferon-inducible protein 16

1

5

High-throughput

0.479

High

1212454

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

1

High-throughput

0.479

High

1246972

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1276744

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1277227

POGZ
Pogo transposable element with ZNF domain

1

4

High-throughput

0.479

High

1286790

KAISO
Transcriptional regulator Kaiso

1

5

High-throughput

0.479

High

1295548

MIB1
E3 ubiquitin-protein ligase MIB1

1

1

High-throughput

0.479

High

1312495

PHC2
Polyhomeotic-like protein 2

1

20

High-throughput

0.479

High

1331041

DDX51
ATP-dependent RNA helicase DDX51

1

13

High-throughput

0.479

High

1336932

PHC3
Polyhomeotic-like protein 3

1

20

High-throughput

0.479

High

1340156

KDM2B
Lysine-specific demethylase 2B

1

20

High-throughput

0.479

High

1368600

KAT6A
Histone acetyltransferase KAT6A

1

18

High-throughput

0.479

High

1390531

CDCA5
Sororin

1

2

High-throughput

0.479

High

1395201

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

14

High-throughput

0.479

High

1401378

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1405632

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1416894

KLF16
Krueppel-like factor 16

1

15

High-throughput

0.479

High

1417790

KDM5D
Lysine-specific demethylase 5D

1

15

Small-scale

0.479

High

1418391

ADNP
Activity-dependent neuroprotector homeobox protein

1

2

High-throughput

0.479

High

1418395

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.479

High

1418397

ELP3
Elongator complex protein 3

1

1

High-throughput

0.479

High

1418406

DJC17
DnaJ homolog subfamily C member 17

1

7

High-throughput

0.479

High

1418408

CDK12
Cyclin-dependent kinase 12

1

14

High-throughput

0.479

High

1418410

RERE
Arginine-glutamic acid dipeptide repeats protein

1

7

High-throughput

0.479

High

1418412

LHX3
LIM/homeobox protein Lhx3

1

8

High-throughput

0.479

High

1418413

ZMYM2
Zinc finger MYM-type protein 2

1

2

High-throughput

0.479

High

1418418

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

1336461

PNMA1
Paraneoplastic antigen Ma1

1

3

High-throughput

0.464

High

1005769

RPP38
Ribonuclease P protein subunit p38

1

0

High-throughput

0.458

High

1240771

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.458

High

1276101

KANL1
KAT8 regulatory NSL complex subunit 1

1

0

High-throughput

0.458

High

1365349

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

1394500

NSL1
Kinetochore-associated protein NSL1 homolog

1

0

High-throughput

0.458

High

1418390

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.458

High

1418392

DSN1
Kinetochore-associated protein DSN1 homolog

1

0

High-throughput

0.458

High

1418396

KANL2
KAT8 regulatory NSL complex subunit 2

1

0

High-throughput

0.458

High

1418409

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.458

High

1418416

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

48384

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

3

High-throughput

0.445

High

611325

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

5

High-throughput

0.445

High

1038350

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

12

High-throughput

0.445

High

1053737

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

5

High-throughput

0.445

High

1116445

FHL1
Four and a half LIM domains protein 1

1

7

High-throughput

0.445

High

1395579

PDLI2
PDZ and LIM domain protein 2

1

3

High-throughput

0.445

High

1418401

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

3

High-throughput

0.445

High

1418405

RBM12
RNA-binding protein 12

1

20

High-throughput

0.445

High

1418407

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

20

High-throughput

0.445

High

294288

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

346282

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

17

High-throughput

0.437

High

1017741

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.437

High

1206963

CEP78
Centrosomal protein of 78 kDa

1

8

High-throughput

0.437

High

1258074

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

1

Small-scale

0.437

High

1275903

EFL1
Elongation factor-like GTPase 1

1

6

High-throughput

0.437

High

1418417

C170B
Centrosomal protein of 170 kDa protein B

1

17

High-throughput

0.437

High

1365178

NDRG1
Protein NDRG1

1

0

High-throughput

0.426

High

1403695

NIBA2
Protein Niban 2

1

0

High-throughput

0.426

High

1418402

PHP14
14 kDa phosphohistidine phosphatase

1

0

High-throughput

0.426

High

955552

CDC42
Cell division control protein 42 homolog

1

1

Small-scale

0.417

High

58924

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.407

High

216329

MGA
Maltase-glucoamylase

1

1

High-throughput

0.407

High

231633

PRKY
Putative serine/threonine-protein kinase PRKY

1

8

High-throughput

0.407

High

360215

GSHR
Glutathione reductase, mitochondrial

1

1

High-throughput

0.407

High

892504

GUAA
GMP synthase [glutamine-hydrolyzing]

1

4

High-throughput

0.407

High

954602

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.407

High

1017602

PR20E
Proline-rich protein 20E

1

1

High-throughput

0.407

High

1418404

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

3

High-throughput

0.407

High

1272465

GDPD3
Lysophospholipase D GDPD3

1

0

High-throughput

0.279

Low

1397241

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.279

Low

890160

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.251

Low

1241187

MSD2
Myb/SANT-like DNA-binding domain-containing protein 2

1

0

High-throughput

0.249

Low

357978

CYB5
Cytochrome b5

1

0

High-throughput

0.232

Low

925680

IST1
IST1 homolog

1

0

High-throughput

0.232

Low

1349931

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.232

Low

1391227

PGM2
Phosphopentomutase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025