Interactor 1: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA
Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.72 | 1.00 | 0.854 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25814554, 10358153, unassigned1126 |
| Identification Methods | two hybrid, enzymatic study, affinity chromatography technology, two hybrid array |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Pkinase~UBA |
| Common GO terms | GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm |
| Homologous interactions | 6 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
