HitPredict

Interactor 1: CXA1 (P17302)
Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)
Gene: GJA1

Interactor 2: DSC2 (Q02487)
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
Gene: DSC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 21220045
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0014704 - intercalated disc
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 382 Hs			1 901
+	Hs
		971036 CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		1055841 CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Rn
		435439 CXA1_RAT (1-382): 0: 546: 97.64		CADH2_RAT (4-385): 5.27e-53: 201: 15.35
+	Mm
		544691 CXA1_MOUSE (1-382): 0: 544: 97.38		CADH2_MOUSE (4-385): 7.27e-53: 201: 15.35
+	Hs
		567051 CXA1_HUMAN (1-382): 0: 545: 100.00		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		1048617 CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18