Protein: P4HA2
Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2)

Gene: P4HA2
Organism: Homo sapiens
Interactions: 169
UniProt ID: O15460

Gene Ontology (top 5):
GO:0004656 - procollagen-proline 4-dioxygenase activity
GO:0005506 - iron ion binding
GO:0005654 - nucleoplasm
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

191280

PDIA1
Protein disulfide-isomerase

6

11

High-throughput

0.938

High

191289

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

2

1

High-throughput

0.759

High

191277

CO1A1
Collagen alpha-1(I) chain

4

11

Small-scale

0.697

High

191334

KIF7
Kinesin-like protein KIF7

4

2

High-throughput

0.694

High

191275

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

3

1

High-throughput

0.662

High

191346

FIP1
Pre-mRNA 3'-end-processing factor FIP1

3

2

High-throughput

0.662

High

191394

WDR33
pre-mRNA 3' end processing protein WDR33

3

5

High-throughput

0.662

High

191295

CO8A2
Collagen alpha-2(VIII) chain

3

13

High-throughput

0.656

High

191358

KI18B
Kinesin-like protein KIF18B

2

1

High-throughput

0.628

High

191288

PDIA4
Protein disulfide-isomerase A4

1

10

High-throughput

0.618

High

191338

TIGD5
Tigger transposable element-derived protein 5

3

2

High-throughput

0.604

High

191373

NEK7
Serine/threonine-protein kinase Nek7

2

0

High-throughput

0.602

High

191283

ARAF
Serine/threonine-protein kinase A-Raf

2

4

High-throughput

0.601

High

191296

CO8A1
Collagen alpha-1(VIII) chain

2

14

High-throughput

0.601

High

191298

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

2

10

High-throughput

0.601

High

191316

TCPB
T-complex protein 1 subunit beta

2

2

High-throughput

0.601

High

191342

IQEC1
IQ motif and SEC7 domain-containing protein 1

2

1

High-throughput

0.601

High

191377

SYMPK
Symplekin

2

1

High-throughput

0.601

High

191388

COCA1

2

7

High-throughput

0.601

High

191389

TCPH
T-complex protein 1 subunit eta

2

1

High-throughput

0.601

High

191364

TENS4
Tensin-4

2

1

High-throughput

0.594

High

191269

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

191375

CTF18
Chromosome transmission fidelity protein 18 homolog

2

0

High-throughput

0.576

High

191335

MA7D1
MAP7 domain-containing protein 1

2

1

High-throughput

0.574

High

191379

TTC28
Tetratricopeptide repeat protein 28

2

3

High-throughput

0.574

High

191312

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

1

High-throughput

0.571

High

191268

CREB3
Cyclic AMP-responsive element-binding protein 3

2

0

High-throughput

0.565

High

191362

RAVR1
Ribonucleoprotein PTB-binding 1

2

1

High-throughput

0.549

High

73974

MYO9A
Unconventional myosin-IXa

1

1

High-throughput

0.536

High

160357

IRS4
Insulin receptor substrate 4

1

1

High-throughput

0.536

High

191266

WDR62
WD repeat-containing protein 62

1

1

High-throughput

0.536

High

191271

DNJB5
DnaJ homolog subfamily B member 5

1

2

High-throughput

0.536

High

191276

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.536

High

191299

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.536

High

191305

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.536

High

191307

TSC2
Tuberin

1

2

High-throughput

0.536

High

191318

COEA1
Collagen alpha-1(XIV) chain

1

8

High-throughput

0.536

High

191322

IFFO1
Non-homologous end joining factor IFFO1

1

1

High-throughput

0.536

High

191324

FOXF2
Forkhead box protein F2

1

4

High-throughput

0.536

High

191333

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

5

High-throughput

0.536

High

191349

CO039
Uncharacterized protein C15orf39

1

2

High-throughput

0.536

High

191360

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

191370

ZN397
Zinc finger protein 397

1

1

High-throughput

0.536

High

191376

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

191398

SAV1
Protein salvador homolog 1

1

2

High-throughput

0.536

High

191402

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.536

High

191411

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

1

2

High-throughput

0.536

High

191418

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

1

2

High-throughput

0.536

High

174856

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.513

High

191270

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.513

High

191272

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.513

High

191290

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

191300

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

0

High-throughput

0.513

High

191304

DPOD2
DNA polymerase delta subunit 2

1

0

High-throughput

0.513

High

191306

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

191308

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.513

High

191323

FP100
Fanconi anemia core complex-associated protein 100

1

0

High-throughput

0.513

High

191327

TRI32
E3 ubiquitin-protein ligase TRIM32

1

0

High-throughput

0.513

High

191329

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

191332

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

High-throughput

0.513

High

191343

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.513

High

191344

TRI65
E3 ubiquitin-protein ligase TRIM65

1

0

High-throughput

0.513

High

191345

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.513

High

191353

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.513

High

191354

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

0

High-throughput

0.513

High

191356

ATG4D
Cysteine protease ATG4D

1

0

High-throughput

0.513

High

191369

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.513

High

191387

ATX2
Ataxin-2

1

0

High-throughput

0.513

High

191390

DCC1
Sister chromatid cohesion protein DCC1

1

0

High-throughput

0.513

High

191391

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

0

High-throughput

0.513

High

191397

SRMS
Tyrosine-protein kinase Srms

1

0

High-throughput

0.513

High

191406

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.513

High

191407

TRM1
tRNA

1

0

High-throughput

0.513

High

191409

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

191416

MCM8
DNA helicase MCM8

1

0

High-throughput

0.513

High

191417

TSR3
18S rRNA aminocarboxypropyltransferase

1

0

High-throughput

0.513

High

191421

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

High-throughput

0.513

High

191303

PRC2A
Protein PRRC2A

1

1

Small-scale

0.508

High

185260

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

191301

PPIC
Peptidyl-prolyl cis-trans isomerase C

1

0

High-throughput

0.493

High

191314

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.493

High

191384

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.493

High

191395

AICDA
Single-stranded DNA cytosine deaminase

1

0

High-throughput

0.493

High

191401

SAS10
Something about silencing protein 10

1

0

High-throughput

0.493

High

191424

MORC2
ATPase MORC2

1

0

High-throughput

0.493

High

191309

DYN2
Dynamin-2

1

0

High-throughput

0.493

High

191386

MA7D2
MAP7 domain-containing protein 2

1

2

High-throughput

0.489

High

191267

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

191273

KI20A
Kinesin-like protein KIF20A

1

4

High-throughput

0.479

High

191302

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

191313

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

191315

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

191328

CUL3
Cullin-3

1

1

High-throughput

0.479

High

191361

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

1

High-throughput

0.479

High

191378

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

191381

SCYL1
N-terminal kinase-like protein

1

2

High-throughput

0.479

High

191382

CALR3
Calreticulin-3

1

3

High-throughput

0.479

High

191413

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

191293

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

191326

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.458

High

191348

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

191420

ALK
ALK tyrosine kinase receptor

1

4

High-throughput

0.457

High

51014

PKHG3
Pleckstrin homology domain-containing family G member 3

1

3

High-throughput

0.445

High

191278

FINC
Fibronectin

1

3

High-throughput

0.445

High

191279

CO5A2

1

11

High-throughput

0.445

High

191281

CO4A2

1

12

High-throughput

0.445

High

191284

COBA1

1

11

High-throughput

0.445

High

191285

CO6A1

1

7

High-throughput

0.445

High

191286

CO6A2

1

7

High-throughput

0.445

High

191287

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

191292

CO5A1

1

11

High-throughput

0.445

High

191310

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.445

High

191317

COAA1

1

14

High-throughput

0.445

High

191319

COGA1

1

14

High-throughput

0.445

High

191325

CSTF3
Cleavage stimulation factor subunit 3

1

3

High-throughput

0.445

High

191366

RUSC2
AP-4 complex accessory subunit RUSC2

1

1

High-throughput

0.445

High

191368

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

191371

COMA1

1

14

High-throughput

0.445

High

191374

ARH40
Rho guanine nucleotide exchange factor 40

1

5

High-throughput

0.445

High

191399

SENP3
Sentrin-specific protease 3

1

2

High-throughput

0.445

High

191419

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

4

High-throughput

0.445

High

191347

SYNE3
Nesprin-3

1

2

High-throughput

0.437

High

191351

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

191403

T106B
Transmembrane protein 106B

1

3

High-throughput

0.437

High

191405

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

1

Small-scale

0.437

High

191422

T22D4
TSC22 domain family protein 4

1

1

High-throughput

0.437

High

191297

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

191380

AJUBA
LIM domain-containing protein ajuba

1

0

High-throughput

0.426

High

191385

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

High-throughput

0.426

High

191404

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.426

High

191412

KLHL9
Kelch-like protein 9

1

0

High-throughput

0.426

High

191265

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

2

High-throughput

0.407

High

191294

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

191337

Q4VAQ0
COL8A2 protein

1

8

High-throughput

0.407

High

191339

COL12
Collectin-12

1

8

High-throughput

0.407

High

191340

IFFO2
Intermediate filament family orphan 2

1

1

High-throughput

0.407

High

191359

C1QL4
Complement C1q-like protein 4

1

5

High-throughput

0.407

High

191365

S39AB
Zinc transporter ZIP11

1

1

High-throughput

0.407

High

191396

SEM6B
Semaphorin-6B

1

1

High-throughput

0.407

High

191423

EMIL1
EMILIN-1

1

7

High-throughput

0.407

High

191415

TSYL4
Testis-specific Y-encoded-like protein 4

2

0

High-throughput

0.328

High

125866

ARVC
Splicing regulator ARVCF

2

0

High-throughput

0.313

High

191355

CLNK
Cytokine-dependent hematopoietic cell linker

2

0

High-throughput

0.300

High

191330

FHL3
Four and a half LIM domains protein 3

1

0

High-throughput

0.299

High

63735

KRBA1
Protein KRBA1

1

0

High-throughput

0.279

Low

66560

CC85C
Coiled-coil domain-containing protein 85C

1

0

High-throughput

0.279

Low

158968

ZN195
Zinc finger protein 195

1

0

High-throughput

0.279

Low

191282

ZN865
Zinc finger protein 865

1

0

High-throughput

0.279

Low

191321

DMWD
Dystrophia myotonica WD repeat-containing protein

1

0

High-throughput

0.279

Low

191331

MELK
Maternal embryonic leucine zipper kinase

1

0

High-throughput

0.279

Low

191336

ERFE
Erythroferrone

1

0

High-throughput

0.279

Low

191350

FA83H
Protein FAM83H

1

0

High-throughput

0.279

Low

191352

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.279

Low

191363

TRM44
Probable tRNA

1

0

High-throughput

0.279

Low

191372

SHKB1
SH3KBP1-binding protein 1

1

0

High-throughput

0.279

Low

191392

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.279

Low

191393

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.279

Low

191400

MYO5C
Unconventional myosin-Vc

1

0

High-throughput

0.279

Low

191341

VP13D
Intermembrane lipid transfer protein VPS13D

1

0

High-throughput

0.269

Low

191410

SACS
Sacsin

1

0

High-throughput

0.269

Low

191291

EFNA1
Ephrin-A1

1

0

High-throughput

0.249

Low

191408

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

191414

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

191274

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

0

High-throughput

0.232

Low

191311

SMTN
Smoothelin

1

0

High-throughput

0.232

Low

191320

LOXL1
Lysyl oxidase homolog 1

1

0

High-throughput

0.232

Low

191357

MEX3D
RNA-binding protein MEX3D

1

0

High-throughput

0.232

Low

191367

VW5B2
von Willebrand factor A domain-containing protein 5B2

1

0

High-throughput

0.232

Low

191383

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025