HitPredict

Interactor 1: CXA1 (P17302)
Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)
Gene: GJA1

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0030054 - cell junction GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 382 Hs			1 2472
+	Rn
		435402 CXA1_RAT (1-382): 0: 546: 97.64		Q6XDA1_RAT (1-2472): 2.23e-153: 534: 53.70
+	Hs
		1045454 CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		297813 CXA1_HUMAN (1-382): 0: 545: 100.00		K0754_HUMAN (1-1482): 9.32e-58: 225: 14.65
+	Hs
		567012 CXA1_HUMAN (1-382): 0: 545: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		567061 CXA1_HUMAN (1-382): 0: 545: 100.00		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		567019 CXA1_HUMAN (1-382): 0: 545: 100.00		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		567331 CXA1_HUMAN (1-382): 0: 545: 100.00		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Rn
		435438 CXA1_RAT (1-382): 0: 546: 97.64		ACTN1_RAT (1862-2210): 1.85e-11: 72: 22.51
+	Hs
		521462 CXA1_HUMAN (1-382): 0: 545: 100.00		ACTN1_HUMAN (1862-2210): 3.16e-11: 71.2: 22.25
+	Rn
		435428 CXA1_RAT (1-382): 0: 546: 97.64		ACTN4_RAT (1843-2219): 3.3e-10: 67.8: 20.30
+	Hs
		164637 CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		963365 CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		1059239 CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		974109 CXD3_HUMAN (1-253): 8.84e-96: 289: 34.39		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59