HitPredict

Interactor 1: CAP (P17555)
Adenylyl cyclase-associated protein (CAP)
Gene: SRV2

Interactor 2: TWF1 (P53250)
Twinfilin-1 (Twinfilin-A)
Gene: TWF1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	26458246, 18467557, 20489023
Identification Methods	transmission electron microscopy, pull down, protein complementation assay, affinity chromatography technology, dihydrofolate reductase reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007015 - actin filament organization GO:0030042 - actin filament depolymerization GO:0030836 - positive regulation of actin filament depolymerization GO:0043332 - mating projection tip and 1 others more... GO:0051014 - actin filament severing
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 526 Sc			1 332
+	Hs
		965198 CAP1_HUMAN (12-526): 0: 630: 32.56		TWF2_HUMAN (1-330): 2.68e-117: 344: 23.30
+	Hs
		965184 CAP1_HUMAN (12-526): 0: 630: 32.56		TWF1_HUMAN (1-330): 1.28e-114: 337: 23.01
+	Hs
		768480 CAP2_HUMAN (12-524): 0: 619: 34.63		TWF2_HUMAN (1-330): 2.68e-117: 344: 23.30
+	Hs
		768472 CAP2_HUMAN (12-524): 0: 619: 34.63		TWF1_HUMAN (1-330): 1.28e-114: 337: 23.01
+	Sc
		568342 CAP_YEAST (1-526): 0: 655: 100.00		COFI_YEAST (1-130): 6.43e-42: 144: 22.14
+	Hs
		618057 CAP1_HUMAN (12-526): 0: 630: 32.56		COF1_HUMAN (4-126): 4.86e-41: 142: 16.28
+	Hs
		618009 CAP2_HUMAN (12-524): 0: 619: 34.63		COF1_HUMAN (4-126): 4.86e-41: 142: 16.28
+	Hs
		768477 CAP2_HUMAN (12-524): 0: 619: 34.63		Q549N0_HUMAN (2-125): 9.17e-40: 139: 20.00
+	Hs
		768490 CAP2_HUMAN (12-524): 0: 619: 34.63		COF2_HUMAN (2-125): 9.17e-40: 139: 20.00
+	Sp
		737042 CAP_SCHPO (10-524): 0: 576: 33.09		COFI_SCHPO (5-130): 5.98e-44: 149: 18.66