HitPredict

Interactor 1: EDN3 (P14138)
Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3)
Gene: EDN3

Interactor 2: MEGF8 (Q7Z7M0)
Multiple epidermal growth factor-like domains protein 8 (Multiple EGF-like domains protein 8) (Epidermal growth factor-like protein 4) (EGF-like protein 4)
Gene: MEGF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0010468 - regulation of gene expression
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 238 Hs			1 2845
+	Hs
		570654 EDN3_HUMAN (1-238): 3.67e-155: 431: 100.00		NOTC1_HUMAN (1837-2585): 1.81e-42: 174: 11.34
+	Hs
		570663 EDN3_HUMAN (1-238): 3.67e-155: 431: 100.00		NOTC2_HUMAN (556-1366): 7.1e-36: 153: 10.15
+	Hs
		296339 EDN3_HUMAN (1-238): 3.67e-155: 431: 100.00		ATRN_HUMAN (447-1261): 5.57e-14: 80.6: 11.78
+	Hs
		570669 EDN3_HUMAN (1-238): 3.67e-155: 431: 100.00		LAMB3_HUMAN (1147-1316): 4.38e-12: 74.3: 30.15
+	Hs
		570656 EDN3_HUMAN (1-238): 3.67e-155: 431: 100.00		LAMB2_HUMAN (853-1167): 2.71e-11: 71.8: 16.06
+	Hs
		570660 EDN3_HUMAN (1-238): 3.67e-155: 431: 100.00		PGBM_HUMAN (1127-1262): 7.22e-11: 70.9: 35.29
+	Hs
		183223 EDN3_HUMAN (1-238): 3.67e-155: 431: 100.00		LAMA5_HUMAN (955-1137): 7.45e-09: 64.1: 19.80