HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: IRS1 (P35568)
Insulin receptor substrate 1 (IRS-1)
Gene: IRS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 0.60 0.629

The method score is based on:

Property Details
Experiments 10660596, 11579209
Identification Methods pull down, affinity chromatography technology, phosphatase assay
Interaction Type direct interaction, physical association, dephosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005158 - insulin receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008286 - insulin receptor signaling pathway
GO:0046627 - negative regulation of insulin receptor signaling pathway
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 435
Hs

1 1242
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024