Protein: XRCC1
DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)

Gene: XRCC1
Organism: Homo sapiens
Interactions: 165
UniProt ID: P18887

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

446508

DPOLB
DNA polymerase beta

13

1

Small-scale

0.985

High

486942

PARP1
Poly [ADP-ribose] polymerase 1

10

3

Small-scale

0.972

High

617665

DNLI3
DNA ligase 3

14

0

Small-scale

0.930

High

557846

XRCC6
X-ray repair cross-complementing protein 6

3

0

High-throughput

0.816

High

617730

PNKP
Bifunctional polynucleotide phosphatase/kinase

9

2

Small-scale

0.755

High

617709

APTX
Aprataxin

6

1

Small-scale

0.747

High

617713

APLF
Aprataxin and PNK-like factor

9

0

Small-scale

0.723

High

617712

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

4

0

Small-scale

0.667

High

617744

TYDP1
Tyrosyl-DNA phosphodiesterase 1

4

0

Small-scale

0.664

High

413160

P53
Cellular tumor antigen p53

1

0

Small-scale

0.656

High

550831

PCNA
Proliferating cell nuclear antigen

3

0

Small-scale

0.642

High

259419

BRD4
Bromodomain-containing protein 4

3

2

High-throughput

0.640

High

617680

H31
Histone H3.1

3

1

High-throughput

0.640

High

617654

APEX1
DNA repair nuclease/redox regulator APEX1

3

0

Small-scale

0.632

High

617743

RN146
E3 ubiquitin-protein ligase RNF146

3

0

Small-scale

0.628

High

587883

RFA2
Replication protein A 32 kDa subunit

3

0

High-throughput

0.628

High

617751

DPOLL
DNA polymerase lambda

1

1

Small-scale

0.618

High

617653

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

0

Small-scale

0.613

High

418823

H2A1B
Histone H2A type 1-B/E

2

2

High-throughput

0.611

High

617718

H2B1A
Histone H2B type 1-A

2

2

High-throughput

0.611

High

617679

CSK21
Casein kinase II subunit alpha

2

0

Small-scale

0.598

High

617725

NEIL1
Endonuclease 8-like 1

2

0

Small-scale

0.592

High

617655

DPOD1
DNA polymerase delta catalytic subunit

1

0

Small-scale

0.586

High

617745

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.586

High

617663

SOX2
Transcription factor SOX-2

2

1

High-throughput

0.584

High

617675

H2B1C
Histone H2B type 1-C/E/F/G/I

2

2

High-throughput

0.584

High

617683

H33
Histone H3.3

2

1

High-throughput

0.584

High

354898

CHK2
Serine/threonine-protein kinase Chk2

1

0

Small-scale

0.583

High

617677

UBC9
SUMO-conjugating enzyme UBC9

2

0

Small-scale

0.577

High

617649

XRCC1
DNA repair protein XRCC1

1

1

Small-scale

0.575

High

395462

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

617659

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

617681

PRKDC
DNA-dependent protein kinase catalytic subunit

2

0

Small-scale

0.559

High

617727

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

0

Small-scale

0.554

High

348354

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

0

High-throughput

0.547

High

617742

TOPRS
E3 ubiquitin-protein ligase Topors

1

0

Small-scale

0.537

High

617759

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.537

High

220858

XPOT
Exportin-T

1

1

High-throughput

0.536

High

502232

H2A1
Histone H2A type 1

1

2

High-throughput

0.536

High

591471

H2AX
Histone H2AX

1

2

High-throughput

0.536

High

617668

BRPF1
Peregrin

1

1

High-throughput

0.536

High

617670

DLX6
Homeobox protein DLX-6

1

1

High-throughput

0.536

High

617705

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

617733

FOXB1
Forkhead box protein B1

1

2

High-throughput

0.536

High

617739

FOXP1
Forkhead box protein P1

1

2

High-throughput

0.536

High

617754

FOXD3
Forkhead box protein D3

1

2

High-throughput

0.536

High

617672

MAX
Protein max

1

0

High-throughput

0.530

High

617756

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.517

High

617703

BRD3
Bromodomain-containing protein 3

1

4

High-throughput

0.515

High

617758

POLI
DNA polymerase iota

1

1

Small-scale

0.515

High

155283

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.513

High

166116

AIM2
Interferon-inducible protein AIM2

1

0

High-throughput

0.513

High

216228

PPIH
Peptidyl-prolyl cis-trans isomerase H

1

0

High-throughput

0.513

High

541817

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

549280

SRF
Serum response factor

1

0

High-throughput

0.513

High

571553

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.513

High

593018

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.513

High

617678

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.513

High

617682

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

617685

EMX2
Homeobox protein EMX2

1

0

High-throughput

0.513

High

617687

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.513

High

617688

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

617698

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

617700

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

617711

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

617720

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.513

High

617726

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.513

High

617736

SSBP3
Single-stranded DNA-binding protein 3

1

0

High-throughput

0.513

High

617746

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

0

High-throughput

0.513

High

617752

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

High-throughput

0.513

High

617760

SF3B6
Splicing factor 3B subunit 6

1

0

High-throughput

0.513

High

617762

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

193362

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

Small-scale

0.504

High

617690

KLF10
Krueppel-like factor 10

1

1

High-throughput

0.500

High

617731

KLF6
Krueppel-like factor 6

1

1

High-throughput

0.500

High

617721

GCC1
GRIP and coiled-coil domain-containing protein 1

1

1

High-throughput

0.489

High

617735

DPH7
Diphthine methyltransferase

1

1

High-throughput

0.489

High

617661

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.479

High

142826

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

172458

XPO1
Exportin-1

1

1

Small-scale

0.479

High

285072

EED
Polycomb protein EED

1

2

High-throughput

0.479

High

440353

FYN
Tyrosine-protein kinase Fyn

1

1

High-throughput

0.479

High

473779

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

606196

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

617652

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.479

High

617662

NKX21
Homeobox protein Nkx-2.1

1

1

High-throughput

0.479

High

617664

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.479

High

617669

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

617689

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

617699

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.479

High

617702

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

617748

POLK
DNA polymerase kappa

1

1

Small-scale

0.479

High

617750

PARP2
Poly [ADP-ribose] polymerase 2

1

1

Small-scale

0.479

High

128767

MEN1
Menin

1

0

High-throughput

0.458

High

190811

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

247662

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

254326

CC14B
Dual specificity protein phosphatase CDC14B

1

0

High-throughput

0.458

High

281143

DPOLQ
DNA polymerase theta

1

0

Small-scale

0.458

High

385444

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

461129

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.458

High

529042

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

617650

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

617651

CCNO
Cyclin-O

1

0

Small-scale

0.458

High

617656

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.458

High

617658

MERL
Merlin

1

0

High-throughput

0.458

High

617660

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

617666

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

617667

RD23B
UV excision repair protein RAD23 homolog B

1

0

Small-scale

0.458

High

617673

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

617674

H4
Histone H4

1

0

High-throughput

0.458

High

617676

RAN
GTP-binding nuclear protein Ran

1

0

Small-scale

0.458

High

617686

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

617692

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

617693

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.458

High

617695

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

High-throughput

0.458

High

617696

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.458

High

617697

CUL1
Cullin-1

1

0

Small-scale

0.458

High

617704

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

617714

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

617722

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

617723

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

617724

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.458

High

617729

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

617732

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.458

High

617734

CND3
Condensin complex subunit 3

1

0

Small-scale

0.458

High

617749

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

617761

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

501909

H2AZ
Histone H2A.Z

1

3

Small-scale

0.445

High

617657

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

617707

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

617715

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

1

High-throughput

0.445

High

617747

GRHL1
Grainyhead-like protein 1 homolog

1

1

High-throughput

0.445

High

617717

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

617740

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

617757

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

402847

ANXA1
Annexin A1

1

0

Small-scale

0.391

High

617763

PCDBB
Protocadherin beta-11

2

0

High-throughput

0.328

High

617719

RN166
E3 ubiquitin-protein ligase RNF166

2

0

High-throughput

0.318

High

617728

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.313

High

231298

EFNA2
Ephrin-A2

1

0

High-throughput

0.279

Low

338668

VNN1
Pantetheinase

1

0

High-throughput

0.279

Low

518807

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.279

Low

611760

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.279

Low

617671

RAP1B
Ras-related protein Rap-1b

1

0

High-throughput

0.279

Low

617691

LIPA1
Liprin-alpha-1

1

0

High-throughput

0.279

Low

617694

OS9
Protein OS-9

1

0

High-throughput

0.279

Low

617716

TBCK
TBC domain-containing protein kinase-like protein

1

0

High-throughput

0.279

Low

617738

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.279

Low

617741

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.279

Low

617755

S39AA
Zinc transporter ZIP10

1

0

High-throughput

0.279

Low

105298

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

156942

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

297142

PRAF3
PRA1 family protein 3

1

0

Small-scale

0.249

Low

411327

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

488718

FURIN
Furin

1

0

High-throughput

0.249

Low

617684

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low

617701

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

617708

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

617737

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

58791

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.232

Low

254793

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

617706

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

617710

SL9B2
Sodium/hydrogen exchanger 9B2

1

0

High-throughput

0.232

Low

617753

SO3A1
Solute carrier organic anion transporter family member 3A1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025