HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: STYK1 (Q6J9G0)
Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
Gene: STYK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 422
+	Hs
		507839 PTN1_HUMAN (1-435): 0: 539: 100.00		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		573629 PTN1_HUMAN (1-435): 0: 539: 100.00		EPHA5_HUMAN (2-408): 4.94e-121: 377: 20.33
+	Hs
		434132 PTN1_HUMAN (1-435): 0: 539: 100.00		RET_HUMAN (8-415): 2.01e-119: 375: 23.29
+	Hs
		169163 PTN1_HUMAN (1-435): 0: 539: 100.00		MUSK_HUMAN (24-393): 4.95e-119: 368: 22.28
+	Hs
		522755 PTN1_HUMAN (1-435): 0: 539: 100.00		SRC_HUMAN (90-390): 1.63e-110: 336: 28.95
+	Hs
		522754 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		SRC_HUMAN (90-390): 1.63e-110: 336: 28.95
+	Hs
		601500 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		FGFR2_HUMAN (29-417): 7.84e-125: 382: 23.64
+	Hs
		507980 PTPRS_HUMAN (1-278): 3.66e-109: 355: 30.74		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		607948 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79
+	Hs
		337339 PTN1_HUMAN (1-435): 0: 539: 100.00		ABL1_HUMAN (143-387): 8.6e-41: 156: 35.34
+	Hs
		412016 PTPRD_HUMAN (1-278): 8.51e-109: 354: 31.45		FYN_HUMAN (92-390): 1.01e-109: 334: 28.33
+	Mm
		56907 PTPRF_MOUSE (19-278): 5.35e-106: 346: 31.32		FYN_MOUSE (92-390): 1.41e-109: 334: 28.33
+	Hs
		411959 PTPRF_HUMAN (19-278): 2.99e-105: 344: 30.94		FYN_HUMAN (92-390): 1.01e-109: 334: 28.33
+	Hs
		616905 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		CSK_HUMAN (144-386): 2.31e-36: 140: 36.89
+	Hs
		616913 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		TIE2_HUMAN (146-380): 2.39e-34: 137: 31.56
+	Hs
		725305 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		TIE1_HUMAN (120-380): 8.51e-36: 142: 32.96
+	Hs
		782783 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		CSK_HUMAN (144-386): 2.31e-36: 140: 36.89
+	Hs
		972322 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		TIE2_HUMAN (146-380): 2.39e-34: 137: 31.56
+	Hs
		782777 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		CSK_HUMAN (144-386): 2.31e-36: 140: 36.89
+	Hs
		972318 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		TIE2_HUMAN (146-380): 2.39e-34: 137: 31.56