HitPredict

Interactor 1: RD21L (A2AU37)
Double-strand-break repair protein rad21-like protein 1
Gene: Rad21l1

Interactor 2: SMC1A (Q9CU62)
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Chromosome segregation protein SmcB) (Sb1.8)
Gene: SMC1A

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	24797475
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Rad21_Rec8~SMC_N, Rad21_Rec8_N~SMC_N
Common GO terms	GO:0000800 - lateral element GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0007062 - sister chromatid cohesion GO:0008278 - cohesin complex and 1 others more... GO:0030893 - meiotic cohesin complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 552 Mm			1 1233
+	Mm
		57597 RD21L_MOUSE (1-552): 0: 630: 100.00		SMC1B_MOUSE (1-1233): 5.95e-101: 350: 51.83
+	Hs
		224434 RAD21_HUMAN (1-550): 0: 525: 40.41		SMC1A_HUMAN (1-1233): 1.18e-125: 419: 99.84
+	Mm
		1142821 RAD21_MOUSE (1-550): 7.47e-178: 517: 39.94		SMC1A_MOUSE (1-1233): 5.26e-126: 420: 100.00
+	Xl
		292726 RAD21_XENLA (1-552): 1.56e-178: 519: 40.79		SMC1A_XENLA (1-1232): 1.2e-119: 402: 93.99
+	Hs
		224479 RAD21_HUMAN (1-550): 0: 525: 40.41		SMC1B_HUMAN (1-1233): 3.31e-107: 368: 53.20
+	Mm
		57599 RD21L_MOUSE (1-552): 0: 630: 100.00		SMC3_MOUSE (3-1229): 7.9e-70: 258: 16.17
+	Mm
		1142818 RAD21_MOUSE (1-550): 7.47e-178: 517: 39.94		SMC1B_MOUSE (1-1233): 5.95e-101: 350: 51.83
+	Hs
		224250 RAD21_HUMAN (1-550): 0: 525: 40.41		SMC2_HUMAN (3-1214): 7.15e-73: 267: 17.88
+	Hs
		224536 RAD21_HUMAN (1-550): 0: 525: 40.41		SMC4_HUMAN (4-1216): 4.21e-71: 263: 20.18
+	Hs
		224554 RAD21_HUMAN (1-550): 0: 525: 40.41		SMC3_HUMAN (3-1229): 1.16e-69: 258: 16.17
+	Xl
		292737 RAD21_XENLA (1-552): 1.56e-178: 519: 40.79		SMC3_XENLA (3-1229): 1.8e-71: 263: 16.27
+	Xl
		1150103 Q6DCL7_XENLA (1-550): 0: 525: 41.24		Q8AW91_XENLA (3-1229): 3.98e-69: 256: 15.90
+	Mm
		1142822 RAD21_MOUSE (1-550): 7.47e-178: 517: 39.94		SMC3_MOUSE (3-1229): 7.9e-70: 258: 16.17
+	Xl
		292746 RAD21_XENLA (1-552): 1.56e-178: 519: 40.79		Q8AW91_XENLA (3-1229): 3.98e-69: 256: 15.90
+	Hs
		304438 REC8_HUMAN (1-550): 5.03e-116: 356: 17.89		SMC1A_HUMAN (1-1233): 1.18e-125: 419: 99.84
+	Hs
		304446 REC8_HUMAN (1-550): 5.03e-116: 356: 17.89		SMC1B_HUMAN (1-1233): 3.31e-107: 368: 53.20
+	Mm
		1207969 REC8_MOUSE (1-549): 2.2e-114: 353: 17.84		SMC1B_MOUSE (1-1233): 5.95e-101: 350: 51.83
+	Sp
		293281 REC8_SCHPO (1-544): 6.73e-115: 353: 15.65		SMC1_SCHPO (1-1225): 3.48e-71: 262: 32.77
+	Hs
		304460 REC8_HUMAN (1-550): 5.03e-116: 356: 17.89		SMC3_HUMAN (3-1229): 1.16e-69: 258: 16.17
+	Sp
		193874 REC8_SCHPO (1-544): 6.73e-115: 353: 15.65		SMC3_SCHPO (3-1225): 1.24e-65: 245: 17.18