Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 0.60 0.749

The method score is based on:

Property Details
Experiments 12061819, 9712732, 12941616, 12803489, 16467851, 17372230, 16503409
Identification Methods pull down, affinity chromatography technology, far western blotting, fluorescent resonance energy transfer
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005509 - calcium ion binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0030971 - receptor tyrosine kinase binding
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 1290
Hs

1 906
+ Mm
+ Hs
+ Mm
+ Mm
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024