HitPredict

Interactor 1: EPOR (P19235)
Erythropoietin receptor (EPO-R)
Gene: EPOR

Interactor 2: STA5A (P42229)
Signal transducer and activator of transcription 5A
Gene: STAT5A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	8977232, 15644415, 10374881
Identification Methods	affinity chromatography technology, pull down, protein complementation assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3, STAT_alpha~fn3
Common GO terms	GO:0019221 - cytokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 794
+	Mm
		562611 GHR_MOUSE (6-486): 3.15e-95: 304: 16.02		STA5A_MOUSE (1-794): 0: 1043: 96.35
+	Mm
		786650 PRLR_MOUSE (30-495): 6.85e-82: 268: 17.57		STA5A_MOUSE (1-794): 0: 1043: 96.35
+	Mm
		557512 IL2RB_MOUSE (21-487): 2.45e-75: 248: 19.09		STA5A_MOUSE (1-794): 0: 1043: 96.35
+	Mm
		562612 GHR_MOUSE (6-486): 3.15e-95: 304: 16.02		STA5B_MOUSE (1-774): 0: 985: 92.17
+	Hs
		500954 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		560469 PRLR_HUMAN (40-499): 4.21e-85: 276: 18.03		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		540452 IL2RB_HUMAN (17-488): 2.49e-64: 220: 17.52		STA5A_HUMAN (1-794): 0: 1050: 100.00
+	Hs
		562533 IL7RA_HUMAN (109-477): 4.76e-65: 219: 15.65		STA5A_HUMAN (1-794): 0: 1050: 100.00
+	Mm
		557513 IL2RB_MOUSE (21-487): 2.45e-75: 248: 19.09		STA5B_MOUSE (1-774): 0: 985: 92.17
+	Hs
		540455 IL2RB_HUMAN (17-488): 2.49e-64: 220: 17.52		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Mm
		562610 GHR_MOUSE (6-486): 3.15e-95: 304: 16.02		STAT3_MOUSE (1-723): 0: 737: 29.94
+	Hs
		500951 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		540451 IL2RB_HUMAN (17-488): 2.49e-64: 220: 17.52		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Hs
		562532 IL7RA_HUMAN (109-477): 4.76e-65: 219: 15.65		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Hs
		540449 IL2RB_HUMAN (17-488): 2.49e-64: 220: 17.52		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		562528 IL7RA_HUMAN (109-477): 4.76e-65: 219: 15.65		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		786348 I13R2_HUMAN (22-284): 2.33e-52: 183: 16.67		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Hs
		540463 IL2RB_HUMAN (17-488): 2.49e-64: 220: 17.52		STAT4_HUMAN (1-738): 0: 715: 29.34
+	Hs
		776798 CSF3R_HUMAN (14-425): 2.42e-50: 186: 13.92		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		622729 IL4RA_HUMAN (48-496): 2.05e-38: 151: 14.78		STAT6_HUMAN (1-766): 0: 720: 37.71