HitPredict

Interactor 1: EPOR (P19235)
Erythropoietin receptor (EPO-R)
Gene: EPOR

Interactor 2: CISH (Q9NSE2)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	28038963, 7796808, 16961462, 15644415, 9774439, 11781573
Identification Methods	affinity chromatography technology, protein complementation assay, pull down, anti tag coimmunoprecipitation, mammalian protein protein interaction trap
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 258
+	Mm
		540271 EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69		CISH_MOUSE (1-258): 3.74e-69: 215: 90.31
+	Hs
		146592 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		147386 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		522759 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		SRC_HUMAN (50-248): 5.15e-42: 152: 16.11
+	Mm
		540265 EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69		LYN_MOUSE (47-215): 6.97e-40: 146: 16.38
+	Mm
		193372 EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69		SOCS3_MOUSE (43-254): 1.24e-40: 141: 29.77
+	Hs
		581161 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		581150 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Rn
		70070 GHR_RAT (6-486): 5.8e-94: 300: 16.51		B1WBX9_RAT (1-258): 3.95e-68: 212: 90.31
+	Hs
		433567 EPOR_HUMAN (1-508): 8.71e-145: 427: 100.00		LYN_HUMAN (41-209): 8.26e-18: 84.2: 19.21
+	Mm
		540266 EPOR_MOUSE (1-508): 7.16e-140: 414: 81.69		P85A_MOUSE (52-188): 4.14e-21: 94.1: 16.06
+	Mm
		645937 IL3RB_MOUSE (17-488): 6.93e-85: 282: 18.29		CISH_MOUSE (1-258): 3.74e-69: 215: 90.31
+	Hs
		500974 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		CISH_HUMAN (1-258): 2.61e-67: 210: 100.00
+	Hs
		146586 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		SOCS2_HUMAN (45-258): 1.84e-53: 173: 37.85
+	Hs
		147382 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		SOCS3_HUMAN (44-254): 6.27e-48: 160: 32.42
+	Hs
		181779 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		SOCS1_HUMAN (55-258): 2e-42: 145: 28.16
+	Mm
		562609 GHR_MOUSE (6-486): 3.15e-95: 304: 16.02		PTN11_MOUSE (77-222): 7.34e-26: 107: 19.46
+	Hs
		500960 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		PTN11_HUMAN (77-222): 6.35e-26: 107: 19.46
+	Hs
		500948 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		P85A_HUMAN (52-188): 2.6e-21: 94.5: 16.06
+	Hs
		129180 GHR_HUMAN (6-482): 1.38e-87: 283: 15.10		P85B_HUMAN (52-183): 6.6e-21: 93.4: 17.42