HitPredict

Interactor 1: MED14 (P19263)
Mediator of RNA polymerase II transcription subunit 14 (Glucose repression regulatory protein 1) (Mediator complex subunit 14)
Gene: RGR1

Interactor 2: MED19 (P25046)
Mediator of RNA polymerase II transcription subunit 19 (Hypoxic gene repressor protein 3) (Mediator complex subunit 19) (Negative regulator of URS2 protein 3) (SNF1 suppressor protein 7)
Gene: ROX3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.90	0.861

The method score is based on:

Property	Details
Experiments	11805826, 9891034, 11555651, 37968396, 16429126
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Med14~Rox3
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003712 - transcription coregulator activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0016592 - mediator complex and 5 others more... GO:0032968 - positive regulation of transcription elongation by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0070847 - core mediator complex
Homologous interactions	0

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Last updated: 15 Jul 2024