HitPredict

Interactor 1: MED14 (P19263)
Mediator of RNA polymerase II transcription subunit 14 (Glucose repression regulatory protein 1) (Mediator complex subunit 14)
Gene: RGR1

Interactor 2: MED10 (Q06213)
Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (Negative regulator of URS2 protein 2)
Gene: NUT2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.966

The method score is based on:

Property	Details
Experiments	9891034, 11555651, 10082564, 16429126, 37968396, 15477388, 27688401, 21498544
Identification Methods	affinity chromatography technology, two hybrid, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Med10~Med14
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003712 - transcription coregulator activity GO:0005634 - nucleus GO:0016592 - mediator complex GO:0032968 - positive regulation of transcription elongation by RNA polymerase II and 4 others more... GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0070847 - core mediator complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	1082
Sc

1	157

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024