HitPredict

Interactor 1: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Interactor 2: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 710 Hs			1 740
+	Hs
		582536 NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00		KS6B2_HUMAN (419-727): 5.97e-118: 364: 29.66
+	Rn
		1144336 PABP1_RAT (222-482): 5.13e-43: 167: 15.55		AKT3_RAT (390-739): 1.71e-123: 379: 22.10
+	Hs
		516724 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		KS6B2_HUMAN (419-727): 5.97e-118: 364: 29.66
+	Hs
		516351 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Hs
		568649 PABP4_HUMAN (222-488): 1.86e-42: 165: 14.88		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Hs
		568550 ELAV4_HUMAN (464-709): 5.73e-44: 164: 18.82		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Hs
		116962 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		SGK1_HUMAN (428-724): 5.73e-27: 116: 29.36