HitPredict

Interactor 1: NUCL (P19338)
Nucleolin (Protein C23)
Gene: NCL

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	26725010, 29845934, 35271311, 18281698
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:1990904 - ribonucleoprotein complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 710 Hs			1 582
+	Hs
		516541 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		403080 NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		516355 NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		582477 NUCL_HUMAN (1-650): 8.84e-98: 318: 100.00		MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42
+	Mm
		449421 NUCL_MOUSE (1-650): 6.1e-99: 321: 76.07		ELAV1_MOUSE (92-211): 6.43e-13: 71.9: 22.50
+	Sc
		376709 PABP_YEAST (181-555): 3.61e-53: 194: 17.47		LHP1_YEAST (7-270): 1.34e-45: 163: 22.74
+	Hs
		1174835 PABP5_HUMAN (233-555): 7.34e-51: 183: 17.20		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		516635 PABP5_HUMAN (233-555): 7.34e-51: 183: 17.20		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		1268142 PABP5_HUMAN (233-555): 7.34e-51: 183: 17.20		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Sc
		376562 PABP_YEAST (181-555): 3.61e-53: 194: 17.47		PABP_YEAST (9-243): 8.44e-33: 134: 13.47
+	Hs
		516495 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		516339 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		516568 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		474034 PABP5_HUMAN (233-555): 7.34e-51: 183: 17.20		PAB4L_HUMAN (1-203): 9.24e-35: 136: 11.85
+	Hs
		516616 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Mm
		665745 PABP1_MOUSE (222-482): 5.43e-43: 167: 15.55		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		1162644 PABP5_HUMAN (233-555): 7.34e-51: 183: 17.20		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		1119141 PABP5_HUMAN (233-555): 7.34e-51: 183: 17.20		PAP1L_HUMAN (2-131): 1.6e-11: 69.2: 11.54
+	Hs
		516561 PABP1_HUMAN (222-482): 4.4e-43: 167: 15.55		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23