Protein: ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1)

Gene: ATS4, ADAMTS4
Organism: Homo sapiens
Interactions: 63
UniProt ID: O75173

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0002020 - protease binding
GO:0004222 - metalloendopeptidase activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

273738

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

2

11

High-throughput

0.811

High

273737

LRP6
Low-density lipoprotein receptor-related protein 6

1

6

High-throughput

0.691

High

273793

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

1

14

High-throughput

0.691

High

273754

XIAP
E3 ubiquitin-protein ligase XIAP

2

4

High-throughput

0.628

High

273758

TRAF2
TNF receptor-associated factor 2

2

4

High-throughput

0.628

High

273761

BIRC2
Baculoviral IAP repeat-containing protein 2

2

3

High-throughput

0.628

High

273771

FRAS1
Extracellular matrix organizing protein FRAS1

2

20

High-throughput

0.628

High

273795

LOXL2
Lysyl oxidase homolog 2

2

4

High-throughput

0.628

High

273736

LRP5
Low-density lipoprotein receptor-related protein 5

1

6

High-throughput

0.618

High

136578

MANBA
Beta-mannosidase

2

1

High-throughput

0.574

High

186311

RA51B
DNA repair protein RAD51 homolog 2

2

1

High-throughput

0.574

High

273756

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

3

High-throughput

0.574

High

273762

TBB3
Tubulin beta-3 chain

2

4

High-throughput

0.574

High

273769

TBA1A
Tubulin alpha-1A chain

2

5

High-throughput

0.574

High

273777

K0232
Uncharacterized protein KIAA0232

2

1

High-throughput

0.574

High

273785

TBB1
Tubulin beta-1 chain

2

6

High-throughput

0.574

High

273788

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

2

2

High-throughput

0.574

High

273794

DICER
Endoribonuclease Dicer

2

1

High-throughput

0.574

High

273739

NOE2
Noelin-2

1

2

High-throughput

0.536

High

273743

TBB5
Tubulin beta chain

1

4

High-throughput

0.536

High

273745

BGLR
Beta-glucuronidase

1

1

High-throughput

0.536

High

273750

BMP8B
Bone morphogenetic protein 8B

1

6

High-throughput

0.536

High

273753

TBA4A
Tubulin alpha-4A chain

1

4

High-throughput

0.536

High

273760

OS9
Protein OS-9

1

1

High-throughput

0.536

High

273775

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

1

High-throughput

0.536

High

273747

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.513

High

273780

LGMN
Legumain

1

0

High-throughput

0.513

High

273783

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.513

High

273787

RISC
Retinoid-inducible serine carboxypeptidase

1

0

High-throughput

0.513

High

273740

A1AT
Alpha-1-antitrypsin

1

1

Small-scale

0.506

High

273751

TIMP3
Metalloproteinase inhibitor 3

1

5

Small-scale

0.501

High

219058

RA51C
DNA repair protein RAD51 homolog 3

1

1

High-throughput

0.489

High

273742

INSR
Insulin receptor

1

12

High-throughput

0.489

High

273744

IGF1R
Insulin-like growth factor 1 receptor

1

10

High-throughput

0.489

High

273746

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.489

High

273748

IDS
Iduronate 2-sulfatase

1

3

High-throughput

0.489

High

273749

ACHA5
Neuronal acetylcholine receptor subunit alpha-5

1

1

High-throughput

0.489

High

273763

RCN2
Reticulocalbin-2

1

1

High-throughput

0.489

High

273765

TRBP2
RISC-loading complex subunit TARBP2

1

1

High-throughput

0.489

High

273766

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

1

High-throughput

0.489

High

273767

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

4

High-throughput

0.489

High

273772

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

4

High-throughput

0.489

High

273773

P3H3
Prolyl 3-hydroxylase 3

1

2

High-throughput

0.489

High

273776

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

2

High-throughput

0.489

High

273778

SC65
Endoplasmic reticulum protein SC65

1

2

High-throughput

0.489

High

273781

TBA1C
Tubulin alpha-1C chain

1

5

High-throughput

0.489

High

273784

TOR3A
Torsin-3A

1

1

High-throughput

0.489

High

273790

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

1

High-throughput

0.489

High

273779

YTDC1
YTH domain-containing protein 1

1

1

High-throughput

0.481

High

273791

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

1

High-throughput

0.479

High

273757

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.460

High

273759

MTA1
Metastasis-associated protein MTA1

1

0

High-throughput

0.458

High

273741

AACT
Alpha-1-antichymotrypsin

1

1

Small-scale

0.457

High

273755

TFAP4
Transcription factor AP-4

2

0

High-throughput

0.328

High

273770

DPH6
Diphthine--ammonia ligase

2

0

High-throughput

0.328

High

273774

CCD33
Coiled-coil domain-containing protein 33

2

0

High-throughput

0.328

High

273782

ITPA
Inosine triphosphate pyrophosphatase

2

0

High-throughput

0.328

High

273789

MKS1
Tectonic-like complex member MKS1

2

0

High-throughput

0.328

High

273764

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.279

Low

273768

GT253
Inactive glycosyltransferase 25 family member 3

1

0

High-throughput

0.279

Low

273792

FEZ2
Fasciculation and elongation protein zeta-2

1

0

High-throughput

0.279

Low

273786

NSUN3
tRNA

1

0

High-throughput

0.269

Low

273752

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025