HitPredict

Interactor 1: CD53 (P19397)
Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)
Gene: CD53

Interactor 2: STX2 (P32856)
Syntaxin-2 (Epimorphin)
Gene: STX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.606

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 219 Hs			1 288
+	Hs
		602225 CD9_HUMAN (2-217): 7.99e-49: 160: 25.88		STX2_HUMAN (1-288): 5.69e-82: 250: 100.00
+	Hs
		887864 CD81_HUMAN (4-214): 3.1e-48: 159: 28.26		STX1A_HUMAN (1-286): 4.14e-76: 235: 64.46
+	Hs
		580342 TSN8_HUMAN (4-213): 3.89e-39: 136: 30.64		STX2_HUMAN (1-288): 5.69e-82: 250: 100.00
+	Hs
		905510 TSN5_HUMAN (7-214): 8.74e-54: 175: 22.53		STX4_HUMAN (1-286): 1.23e-60: 196: 42.57
+	Hs
		602251 CD9_HUMAN (2-217): 7.99e-49: 160: 25.88		STX4_HUMAN (1-286): 1.23e-60: 196: 42.57
+	Hs
		887828 CD81_HUMAN (4-214): 3.1e-48: 159: 28.26		STX4_HUMAN (1-286): 1.23e-60: 196: 42.57
+	Hs
		602253 CD9_HUMAN (2-217): 7.99e-49: 160: 25.88		STX3_HUMAN (1-287): 6.25e-60: 194: 63.79
+	Hs
		326062 TSN15_HUMAN (9-211): 3.34e-40: 140: 19.84		STX4_HUMAN (1-286): 1.23e-60: 196: 42.57
+	Dm
		1178286 Q7JZI2_DROME (4-211): 7.7e-46: 153: 23.68		STX4_DROME (16-266): 3.05e-51: 172: 21.51
+	Hs
		178458 CD81_HUMAN (4-214): 3.1e-48: 159: 28.26		STX7_HUMAN (36-284): 1.29e-48: 164: 27.78
+	Hs
		2743 CD81_HUMAN (4-214): 3.1e-48: 159: 28.26		A0A0C4DGE4_HUMAN (46-225): 9.22e-48: 159: 68.89