HitPredict

Interactor 1: TNR1A (P19438)
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
Gene: TNFRSF1A

Interactor 2: ADA17 (P78536)
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)
Gene: ADAM17

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	17010968
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0016020 - membrane GO:0043120 - tumor necrosis factor binding and 1 others more... GO:0045121 - membrane raft
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 455 Hs			1 824
+	Hs
		591302 TNR1B_HUMAN (7-287): 3.18e-45: 165: 19.86		ADA17_HUMAN (1-824): 0: 881: 100.00
+	Hs
		632399 TNR6_HUMAN (1-167): 7.65e-47: 166: 23.21		ADAM7_HUMAN (45-627): 3.36e-112: 361: 19.74