HitPredict

Interactor 1: RXRA (P19793)
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)
Gene: RXRA

Interactor 2: NR0B2 (Q15466)
Nuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner)
Gene: NR0B2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.833

Property	Details
Experiments	10594021, 12198243, 21988832
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 462 Hs			1 257
+	Hs
		587112 RXRA_HUMAN (1-462): 2.11e-175: 501: 100.00		RXRA_HUMAN (20-254): 4.48e-68: 219: 22.13
+	Hs
		587136 RXRA_HUMAN (1-462): 2.11e-175: 501: 100.00		RXRG_HUMAN (9-254): 5.33e-68: 218: 21.55
+	Hs
		490049 RXRA_HUMAN (1-462): 2.11e-175: 501: 100.00		NR2F6_HUMAN (2-255): 1.04e-58: 193: 27.59
+	Hs
		587144 RXRA_HUMAN (1-462): 2.11e-175: 501: 100.00		NR1H2_HUMAN (26-253): 1.16e-56: 189: 19.74
+	Hs
		587209 RXRA_HUMAN (1-462): 2.11e-175: 501: 100.00		NR2E3_HUMAN (3-255): 1.43e-56: 187: 23.57
+	Hs
		587162 RXRA_HUMAN (1-462): 2.11e-175: 501: 100.00		NR1H3_HUMAN (2-253): 8.41e-55: 183: 15.71
+	Hs
		487899 RXRA_HUMAN (1-462): 2.11e-175: 501: 100.00		RARA_HUMAN (49-254): 9.48e-54: 181: 17.48
+	Hs
		500354 RXRA_HUMAN (1-462): 2.11e-175: 501: 100.00		RARB_HUMAN (5-254): 1.41e-52: 178: 16.54
+	Mm
		659690 RXRA_MOUSE (1-462): 5.15e-172: 493: 96.79		NR1H3_MOUSE (3-253): 2.18e-55: 185: 16.15
+	Hs
		587117 RXRA_HUMAN (1-462): 2.11e-175: 501: 100.00		NR4A1_HUMAN (6-256): 4.44e-50: 174: 18.46
+	Mm
		509288 RXRA_MOUSE (1-462): 5.15e-172: 493: 96.79		RARA_MOUSE (48-254): 9.26e-53: 179: 17.39
+	Mm
		659754 RXRG_MOUSE (12-462): 1.02e-143: 420: 71.84		NR1H2_MOUSE (26-253): 4.44e-57: 190: 20.18
+	Hs
		490054 RXRG_HUMAN (12-462): 4.49e-142: 416: 71.84		NR2F6_HUMAN (2-255): 1.04e-58: 193: 27.59
+	Mm
		659756 RXRG_MOUSE (12-462): 1.02e-143: 420: 71.84		NR1H3_MOUSE (3-253): 2.18e-55: 185: 16.15
+	Hs
		818867 RXRG_HUMAN (12-462): 4.49e-142: 416: 71.84		NR1H2_HUMAN (26-253): 1.16e-56: 189: 19.74
+	Hs
		93999 RXRG_HUMAN (12-462): 4.49e-142: 416: 71.84		F1D8P7_HUMAN (26-253): 1.52e-56: 188: 19.74
+	Hs
		487920 RXRG_HUMAN (12-462): 4.49e-142: 416: 71.84		RARA_HUMAN (49-254): 9.48e-54: 181: 17.48
+	Hs
		500357 RXRG_HUMAN (12-462): 4.49e-142: 416: 71.84		RARB_HUMAN (5-254): 1.41e-52: 178: 16.54
+	Hs
		611397 RXRG_HUMAN (12-462): 4.49e-142: 416: 71.84		NR4A1_HUMAN (6-256): 4.44e-50: 174: 18.46