HitPredict

Interactor 1: USP (P20153)
Protein ultraspiracle (Chorion factor 1) (Nuclear receptor subfamily 2 group B member 4) (XR2C)
Gene: USP

Interactor 2: ECR (P34021)
Ecdysone receptor (20-hydroxy-ecdysone receptor) (20E receptor) (EcRH) (Ecdysteroid receptor) (Nuclear receptor subfamily 1 group H member 1)
Gene: ECR

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.982

The method score is based on:

Property Details
Experiments 17956872, 26222308, 14594447, 14977043, 18980211, 7644522, 8524239, 12084064, 15794746, 25393278, 28378812, 18771703, 25242320, 15207730, 14592980, unassigned4
Identification Methods affinity chromatography technology, two hybrid, protein complementation assay, x-ray crystallography, experimental interaction detection
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001046 - core promoter sequence-specific DNA binding
GO:0003677 - DNA binding
GO:0004879 - nuclear receptor activity
and 22 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Dm

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Last updated: 15 Jul 2024