Protein: STXB1
Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)

Gene: STXB1, STXBP1
Organism: Homo sapiens
Interactions: 132
UniProt ID: P61764

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0002576 - platelet degranulation
GO:0003006 - developmental process involved in reproduction
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

963443

STX19
Syntaxin-19

7

20

High-throughput

0.973

High

963424

STX1A
Syntaxin-1A

9

20

Small-scale

0.963

High

963413

STX3
Syntaxin-3

6

20

Small-scale

0.945

High

286641

STX11
Syntaxin-11

5

20

High-throughput

0.939

High

963411

STX5
Syntaxin-5

3

20

High-throughput

0.871

High

746189

STX2
Syntaxin-2

3

20

Small-scale

0.847

High

960338

STX1B
Syntaxin-1B

2

20

Small-scale

0.757

High

963453

SYTL4
Synaptotagmin-like protein 4

5

1

Small-scale

0.709

High

142675

TRI38
E3 ubiquitin-protein ligase TRIM38

4

1

High-throughput

0.709

High

421848

A4
Amyloid-beta precursor protein

3

3

Small-scale

0.667

High

603914

CXA1
Gap junction alpha-1 protein

3

9

High-throughput

0.667

High

529498

TAU
Microtubule-associated protein tau

3

7

Small-scale

0.656

High

124297

HAX1
HCLS1-associated protein X-1

3

0

High-throughput

0.638

High

963425

DGUOK
Deoxyguanosine kinase, mitochondrial

3

0

High-throughput

0.638

High

963427

BOREA
Borealin

3

0

High-throughput

0.638

High

963469

KTU
Protein kintoun

3

0

High-throughput

0.638

High

963470

ARMC1
Armadillo repeat-containing protein 1

3

0

High-throughput

0.638

High

963475

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.638

High

963480

RRP7A
Ribosomal RNA-processing protein 7 homolog A

3

0

High-throughput

0.638

High

963415

TUSC3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3

2

1

High-throughput

0.628

High

963472

GPC5B
G-protein coupled receptor family C group 5 member B

2

8

High-throughput

0.628

High

963409

STX4
Syntaxin-4

1

20

Small-scale

0.618

High

963423

STXB2
Syntaxin-binding protein 2

1

3

High-throughput

0.618

High

963440

SPICE
Spindle and centriole-associated protein 1

2

1

High-throughput

0.606

High

963405

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

2

6

Small-scale

0.602

High

843449

HD
Huntingtin

2

2

High-throughput

0.588

High

241280

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

703524

MK01
Mitogen-activated protein kinase 1

2

0

High-throughput

0.580

High

963430

CENPP
Centromere protein P

2

0

High-throughput

0.580

High

893799

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.573

High

963460

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

2

6

Small-scale

0.571

High

923577

TTC3
E3 ubiquitin-protein ligase TTC3

1

3

High-throughput

0.541

High

361198

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

724382

COR1A
Coronin-1A

1

1

High-throughput

0.536

High

870708

CXA8
Gap junction alpha-8 protein

1

9

High-throughput

0.536

High

963417

LAPM5
Lysosomal-associated transmembrane protein 5

1

1

High-throughput

0.536

High

963428

PLPP4
Phospholipid phosphatase 4

1

3

High-throughput

0.536

High

963439

KIBRA
Protein KIBRA

1

1

High-throughput

0.536

High

963446

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

1

High-throughput

0.536

High

963449

S39A7
Zinc transporter SLC39A7

1

6

High-throughput

0.536

High

963451

HS105
Heat shock protein 105 kDa

1

3

High-throughput

0.536

High

963455

HVCN1
Voltage-gated hydrogen channel 1

1

2

High-throughput

0.536

High

963461

CML1
Chemerin-like receptor 1

1

2

High-throughput

0.536

High

278292

NCOR1
Nuclear receptor corepressor 1

1

2

High-throughput

0.515

High

832298

ID1
DNA-binding protein inhibitor ID-1

1

0

High-throughput

0.513

High

853964

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

906863

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.513

High

963421

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

963435

URP2
Fermitin family homolog 3

1

0

High-throughput

0.513

High

963468

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.513

High

963476

DPOG2
DNA polymerase subunit gamma-2

1

0

High-throughput

0.513

High

869718

MTR1A
Melatonin receptor type 1A

1

1

High-throughput

0.508

High

963416

SQSTM
Sequestosome-1

1

0

Small-scale

0.505

High

169494

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

5

Small-scale

0.501

High

603224

KPCA
Protein kinase C alpha type

1

5

Small-scale

0.501

High

536885

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.500

High

167248

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

641885

DRD4
D(4) dopamine receptor

1

0

High-throughput

0.493

High

848604

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

963431

CERS6
Ceramide synthase 6

1

2

High-throughput

0.489

High

963432

TBCD9
TBC1 domain family member 9

1

3

High-throughput

0.489

High

963442

PHTF2
Protein PHTF2

1

1

High-throughput

0.489

High

963457

CXD4
Gap junction delta-4 protein

1

9

High-throughput

0.489

High

963404

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

5

Small-scale

0.481

High

403949

GCR
Glucocorticoid receptor

1

4

High-throughput

0.479

High

411685

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

531033

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

1

High-throughput

0.479

High

588377

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

695109

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

710157

EPHA2
Ephrin type-A receptor 2

1

11

High-throughput

0.479

High

845581

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

854426

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

1

High-throughput

0.479

High

942527

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.479

High

963399

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

963402

TBA4A
Tubulin alpha-4A chain

1

1

Small-scale

0.479

High

963403

CDK5
Cyclin-dependent kinase 5

1

2

Small-scale

0.479

High

963407

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

High-throughput

0.479

High

963410

TP4A2
Protein tyrosine phosphatase type IVA 2

1

1

Small-scale

0.479

High

963412

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

963422

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

963433

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

963447

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

2

Small-scale

0.479

High

963463

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

4

Small-scale

0.479

High

963401

RUXE
Small nuclear ribonucleoprotein E

1

0

High-throughput

0.458

High

963418

TBB2A
Tubulin beta-2A chain

1

0

Small-scale

0.458

High

963420

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

138469

BIN1
Myc box-dependent-interacting protein 1

1

4

High-throughput

0.457

High

174736

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

5

High-throughput

0.457

High

238810

KALRN
Kalirin

1

5

High-throughput

0.457

High

245450

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

1

High-throughput

0.457

High

555655

ACTN1
Alpha-actinin-1

1

2

High-throughput

0.457

High

963400

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.457

High

963406

DYST
Dystonin

1

4

High-throughput

0.457

High

963434

TCPR1
Tectonin beta-propeller repeat-containing protein 1

1

1

High-throughput

0.457

High

963459

ABCA3
Phospholipid-transporting ATPase ABCA3

1

1

High-throughput

0.457

High

963462

SH3G1
Endophilin-A2

1

2

High-throughput

0.457

High

963467

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

1

High-throughput

0.457

High

963473

ARHGC
Rho guanine nucleotide exchange factor 12

1

5

High-throughput

0.457

High

468237

HS90B
Heat shock protein HSP 90-beta

1

6

High-throughput

0.445

High

954383

SNP25
Synaptosomal-associated protein 25

1

14

Small-scale

0.445

High

963448

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

1

High-throughput

0.445

High

963456

SAAL1
Protein SAAL1

1

3

High-throughput

0.445

High

963458

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.445

High

963478

BCS1
Mitochondrial chaperone BCS1

1

10

High-throughput

0.445

High

963479

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

258098

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.438

High

881027

NASP
Nuclear autoantigenic sperm protein

1

0

High-throughput

0.438

High

911819

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

0

High-throughput

0.438

High

963436

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.438

High

963438

KCMB4
Calcium-activated potassium channel subunit beta-4

1

0

High-throughput

0.438

High

963445

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.438

High

963452

MY18A
Unconventional myosin-XVIIIa

1

0

High-throughput

0.438

High

963464

PARVB
Beta-parvin

1

0

High-throughput

0.438

High

963465

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

963471

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.438

High

963474

PARP2
Poly [ADP-ribose] polymerase 2

1

0

High-throughput

0.438

High

105691

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

963414

PLD1
Phospholipase D1

1

0

Small-scale

0.433

High

254925

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

889957

PSN1
Presenilin-1

1

0

Small-scale

0.426

High

963419

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

963450

NICA
Nicastrin

1

0

Small-scale

0.426

High

963437

SESD1
SEC14 domain and spectrin repeat-containing protein 1

1

6

High-throughput

0.417

High

963441

AN36B
Ankyrin repeat domain-containing protein 36B

1

4

High-throughput

0.417

High

963454

T4S18
Transmembrane 4 L6 family member 18

2

0

High-throughput

0.328

High

963408

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

High-throughput

0.299

High

943462

DSCR6
Protein ripply3

1

0

High-throughput

0.282

High

963466

TM140
Transmembrane protein 140

1

0

High-throughput

0.269

Low

963429

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.238

Low

963444

CC148
Coiled-coil domain-containing protein 148

1

0

High-throughput

0.238

Low

963477

NP1L2
Nucleosome assembly protein 1-like 2

1

0

High-throughput

0.238

Low

963426

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025