Protein: STXB3
Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C)

Gene: STXB3, STXBP3
Organism: Homo sapiens
Interactions: 109
UniProt ID: O00186

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006886 - intracellular protein transport
GO:0006904 - vesicle docking involved in exocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

125737

STX4
Syntaxin-4

7

20

Small-scale

0.959

High

125770

PLPR1
Phospholipid phosphatase-related protein type 1

3

3

High-throughput

0.667

High

125736

ASPH
Aspartyl/asparaginyl beta-hydroxylase

3

1

High-throughput

0.662

High

125732

VAMP2
Vesicle-associated membrane protein 2

1

17

Small-scale

0.647

High

125748

SGMR2
Sigma intracellular receptor 2

3

0

High-throughput

0.638

High

125755

AAGAB
Alpha- and gamma-adaptin-binding protein p34

3

0

High-throughput

0.638

High

125760

GP141
Probable G-protein coupled receptor 141

2

2

High-throughput

0.628

High

125717

STX2
Syntaxin-2

1

20

Small-scale

0.618

High

125792

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

2

1

High-throughput

0.611

High

125786

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.602

High

125790

GPC5B
G-protein coupled receptor family C group 5 member B

2

8

High-throughput

0.601

High

125719

SYUA
Alpha-synuclein

2

3

High-throughput

0.586

High

125696

RASN
GTPase NRas

2

15

High-throughput

0.584

High

125697

RASH
GTPase HRas

2

12

High-throughput

0.584

High

125698

RASK
GTPase KRas

2

15

High-throughput

0.584

High

125730

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

125794

CERT
Ceramide transfer protein

2

0

High-throughput

0.576

High

125767

RN149
E3 ubiquitin-protein ligase RNF149

2

4

High-throughput

0.558

High

125716

CTR1
High affinity cationic amino acid transporter 1

2

9

High-throughput

0.552

High

125712

S1PR1
Sphingosine 1-phosphate receptor 1

1

4

High-throughput

0.536

High

125722

MOT1
Monocarboxylate transporter 1

1

3

High-throughput

0.536

High

125723

SNAA
Alpha-soluble NSF attachment protein

1

9

High-throughput

0.536

High

125738

LAPM5
Lysosomal-associated transmembrane protein 5

1

1

High-throughput

0.536

High

125752

PLPP4
Phospholipid phosphatase 4

1

3

High-throughput

0.536

High

125771

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

1

High-throughput

0.536

High

125789

GPC5D
G-protein coupled receptor family C group 5 member D

1

8

High-throughput

0.536

High

125720

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.518

High

125774

SYNE2
Nesprin-2

1

6

High-throughput

0.515

High

125700

FINC
Fibronectin

1

0

High-throughput

0.513

High

125724

T2R19
Taste receptor type 2 member 19

1

0

High-throughput

0.513

High

125741

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

125747

CC50B
Cell cycle control protein 50B

1

0

High-throughput

0.513

High

125780

STRA6
Receptor for retinol uptake STRA6

1

0

High-throughput

0.513

High

125734

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

High-throughput

0.493

High

125735

KDSR
3-ketodihydrosphingosine reductase

1

3

High-throughput

0.489

High

125745

INF2
Inverted formin-2

1

2

High-throughput

0.489

High

125763

S35F2
Solute carrier family 35 member F2

1

3

High-throughput

0.489

High

125777

CXD4
Gap junction delta-4 protein

1

9

High-throughput

0.489

High

123937

SNP23
Synaptosomal-associated protein 23

1

14

Small-scale

0.479

High

125065

LEG9
Galectin-9

1

1

High-throughput

0.479

High

125689

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

125690

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

125691

XPO1
Exportin-1

1

2

High-throughput

0.479

High

125694

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

125699

IL1B
Interleukin-1 beta

1

1

Small-scale

0.479

High

125701

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

125702

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

1

High-throughput

0.479

High

125703

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

125704

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

125706

UBL4A
Ubiquitin-like protein 4A

1

6

High-throughput

0.479

High

125707

DMD
Dystrophin

1

3

High-throughput

0.479

High

125708

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

125710

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

125715

EPHA2
Ephrin type-A receptor 2

1

10

High-throughput

0.479

High

125721

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

125726

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

125727

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

125728

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

125729

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

125731

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

125733

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

125742

KS6A2
Ribosomal protein S6 kinase alpha-2

1

2

High-throughput

0.479

High

125743

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

125757

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

125759

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

125766

NIN
Ninein

1

4

High-throughput

0.479

High

125778

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

125781

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

4

Small-scale

0.479

High

125783

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

125784

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

125785

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

125787

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

125791

ALK
ALK tyrosine kinase receptor

1

18

High-throughput

0.479

High

125711

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

125739

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

125756

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

125761

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

125775

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.458

High

125782

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

125788

SNTG1
Gamma-1-syntrophin

1

5

Small-scale

0.457

High

125751

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

125753

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

125762

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

7

High-throughput

0.445

High

125769

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

7

High-throughput

0.445

High

125772

MOT10
Monocarboxylate transporter 10

1

3

High-throughput

0.445

High

125773

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

1

High-throughput

0.445

High

125779

S1PR3
Sphingosine 1-phosphate receptor 3

1

3

High-throughput

0.445

High

104798

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

125693

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.437

High

125695

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

125709

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

125714

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

125718

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

125749

EMC4
ER membrane protein complex subunit 4

1

1

High-throughput

0.437

High

125758

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

125725

CD81
CD81 antigen

1

0

High-throughput

0.426

High

125740

S29A2
Equilibrative nucleoside transporter 2

1

0

High-throughput

0.426

High

125713

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.407

High

125754

NPAL3
NIPA-like protein 3

1

2

High-throughput

0.407

High

125768

MFSD8
Major facilitator superfamily domain-containing protein 8

1

2

High-throughput

0.407

High

125776

SAAL1
Protein SAAL1

1

3

High-throughput

0.407

High

125793

S35A3
UDP-N-acetylglucosamine transporter

1

3

High-throughput

0.407

High

125692

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

2

0

High-throughput

0.328

High

125764

TM192
Transmembrane protein 192

2

0

High-throughput

0.313

High

125765

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

125705

CEL2B
Chymotrypsin-like elastase family member 2B

1

0

High-throughput

0.249

Low

125744

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

125746

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.232

Low

125750

NTCP5
Sodium/bile acid cotransporter 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025