HitPredict

Interactor 1: TBP (P20226)
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)
Gene: TBP

Interactor 2: TAF1 (P21675)
Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
Gene: TAF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 29111974, 31753913, 9858607, 9660973, 15870300, 7597030, 9153318, 7680771, 19240132, 17967894, 17375202, 8858156, 9603525, 8995708, 9674425, rtd:7680771, 17884155, 35271311, 15564746
Identification Methods affinity chromatography technology, pull down, biochemical, two hybrid, anti bait coimmunoprecipitation, far western blotting, experimental interaction detection, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains DUF3591~TBP, TBP~TBP-binding
Common GO terms GO:0000785 - chromatin
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0001091 - RNA polymerase II general transcription initiation factor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 7 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 339
Hs

1 1893
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+ Sp
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+ At
+ Sc
+ At

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Last updated: 15 Jul 2024