Protein: SCAF4
SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15)

Gene: SCAF4
Organism: Homo sapiens
Interactions: 131
UniProt ID: O95104

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:1990269 - RNA polymerase II C-terminal domain phosphoserine binding
GO:2000805 - negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

326323

SRPK2
SRSF protein kinase 2

2

5

High-throughput

0.811

High

326287

SNRPA
U1 small nuclear ribonucleoprotein A

1

6

High-throughput

0.691

High

326306

FUS
RNA-binding protein FUS

1

12

High-throughput

0.691

High

326335

RNPS1
RNA-binding protein with serine-rich domain 1

1

5

High-throughput

0.691

High

326338

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

17

High-throughput

0.691

High

326390

ZN346
Zinc finger protein 346

1

1

High-throughput

0.691

High

326391

SRPK3
SRSF protein kinase 3

1

4

High-throughput

0.691

High

326393

TNPO3
Transportin-3

1

7

High-throughput

0.691

High

326331

HLX
H2.0-like homeobox protein

2

20

High-throughput

0.628

High

326347

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

4

High-throughput

0.628

High

326282

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.618

High

326285

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

4

High-throughput

0.618

High

326289

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

6

High-throughput

0.618

High

326301

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

6

High-throughput

0.618

High

326303

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.618

High

326304

CTNA1
Catenin alpha-1

1

3

High-throughput

0.618

High

326320

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.618

High

326337

ELAV1
ELAV-like protein 1

1

4

High-throughput

0.618

High

326342

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

8

High-throughput

0.618

High

326362

CELF1
CUGBP Elav-like family member 1

1

7

High-throughput

0.618

High

326366

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

2

High-throughput

0.618

High

326381

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

3

High-throughput

0.618

High

326388

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.618

High

326389

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

8

High-throughput

0.618

High

130339

SPT5H
Transcription elongation factor SPT5

2

13

High-throughput

0.611

High

326334

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

1

High-throughput

0.609

High

326314

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.586

High

326313

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.585

High

280442

PR40A
Pre-mRNA-processing factor 40 homolog A

2

19

High-throughput

0.584

High

326295

RFA2
Replication protein A 32 kDa subunit

2

9

High-throughput

0.584

High

326298

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

4

High-throughput

0.584

High

326302

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

7

High-throughput

0.584

High

326305

RFA3
Replication protein A 14 kDa subunit

2

7

High-throughput

0.584

High

326340

LARP7
La-related protein 7

1

8

Small-scale

0.575

High

326376

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.575

High

326281

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

326354

DJC10
DnaJ homolog subfamily C member 10

1

3

High-throughput

0.553

High

191500

MAGB2
Melanoma-associated antigen B2

1

2

High-throughput

0.536

High

192768

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

1

High-throughput

0.536

High

325454

CCNB2
G2/mitotic-specific cyclin-B2

1

1

High-throughput

0.536

High

326284

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

326288

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.536

High

326292

TOP1
DNA topoisomerase 1

1

4

High-throughput

0.536

High

326294

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

5

High-throughput

0.536

High

326297

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

326299

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.536

High

326307

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.536

High

326316

RUXF
Small nuclear ribonucleoprotein F

1

2

High-throughput

0.536

High

326321

SUMO1
Small ubiquitin-related modifier 1

1

5

High-throughput

0.536

High

326326

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

326339

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

326341

KLH22
Kelch-like protein 22

1

6

High-throughput

0.536

High

326344

TRI68
E3 ubiquitin-protein ligase TRIM68

1

2

High-throughput

0.536

High

326392

RL36
Large ribosomal subunit protein eL36

1

1

High-throughput

0.536

High

286417

WBP4
WW domain-binding protein 4

1

8

High-throughput

0.527

High

326283

PRM2
Protamine-2

1

0

High-throughput

0.513

High

326333

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.513

High

326346

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.513

High

326352

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

326363

FGF13
Fibroblast growth factor 13

1

0

High-throughput

0.513

High

326377

ZN287
Zinc finger protein 287

1

0

High-throughput

0.513

High

326394

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

326372

P63
Tumor protein 63

1

8

Small-scale

0.508

High

326328

GAGE5
G antigen 5

1

2

High-throughput

0.489

High

326343

CP141
Cilia- and flagella-associated protein 141

1

1

High-throughput

0.489

High

326385

PEN2
Gamma-secretase subunit PEN-2

1

1

High-throughput

0.489

High

239513

MED14
Mediator of RNA polymerase II transcription subunit 14

1

16

High-throughput

0.479

High

262463

MCE1
mRNA-capping enzyme

1

2

High-throughput

0.479

High

285014

EED
Polycomb protein EED

1

14

High-throughput

0.479

High

287747

MED6
Mediator of RNA polymerase II transcription subunit 6

1

1

High-throughput

0.479

High

316236

RECQ5
ATP-dependent DNA helicase Q5

1

5

High-throughput

0.479

High

326279

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

326286

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

326290

H2AB2
Histone H2A-Bbd type 2/3

1

5

High-throughput

0.479

High

326296

CEBPB
CCAAT/enhancer-binding protein beta

1

17

High-throughput

0.479

High

326300

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

16

High-throughput

0.479

High

326309

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

326311

MECP2
Methyl-CpG-binding protein 2

1

12

High-throughput

0.479

High

326315

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.479

High

326317

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

High-throughput

0.479

High

326318

H4
Histone H4

1

5

High-throughput

0.479

High

326324

VIGLN
Vigilin

1

6

High-throughput

0.479

High

326325

TLE3
Transducin-like enhancer protein 3

1

8

High-throughput

0.479

High

326327

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

326330

MED21
Mediator of RNA polymerase II transcription subunit 21

1

1

High-throughput

0.479

High

326332

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

326336

MED1
Mediator of RNA polymerase II transcription subunit 1

1

8

High-throughput

0.479

High

326351

SPT6H
Transcription elongation factor SPT6

1

2

High-throughput

0.479

High

326353

NAA40
N-alpha-acetyltransferase 40

1

6

High-throughput

0.479

High

326356

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

326359

SP7
Transcription factor Sp7

1

11

High-throughput

0.479

High

326360

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

326361

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

326364

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

7

High-throughput

0.479

High

326368

BARD1
BRCA1-associated RING domain protein 1

1

5

High-throughput

0.479

High

326374

SFR19
Splicing factor, arginine/serine-rich 19

1

7

High-throughput

0.479

High

326375

MED20
Mediator of RNA polymerase II transcription subunit 20

1

1

High-throughput

0.479

High

326382

RNC
Ribonuclease 3

1

8

High-throughput

0.479

High

326383

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

326384

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.479

High

326386

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

326387

WWOX
WW domain-containing oxidoreductase

1

5

High-throughput

0.479

High

48885

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.458

High

326278

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.458

High

326308

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

326312

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

326319

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

326348

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.458

High

326355

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

326357

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

326358

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

326365

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.458

High

326367

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

326369

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

High-throughput

0.458

High

326370

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

326371

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.458

High

326378

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

326379

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

271784

OBSL1
Obscurin-like protein 1

1

5

High-throughput

0.437

High

326280

RASK
GTPase KRas

1

8

High-throughput

0.437

High

326322

ACTC
Actin, alpha cardiac muscle 1

1

13

High-throughput

0.437

High

326349

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.437

High

326373

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.437

High

326350

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.426

High

326310

CEBPA
CCAAT/enhancer-binding protein alpha

1

19

High-throughput

0.408

High

326380

LUC7L
Putative RNA-binding protein Luc7-like 1

3

0

High-throughput

0.347

High

288160

CLC3A
C-type lectin domain family 3 member A

1

0

High-throughput

0.279

Low

326329

S13A2
Solute carrier family 13 member 2

1

0

High-throughput

0.279

Low

326293

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.249

Low

326345

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

326291

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025