Protein: RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

Gene: RPRD2
Organism: Homo sapiens
Interactions: 143
UniProt ID: Q5VT52

Gene Ontology (top 5):
GO:0000993 - RNA polymerase II complex binding
GO:0005654 - nucleoplasm
GO:0031124 - mRNA 3'-end processing
GO:0097550 - transcription preinitiation complex
GO:0099122 - RNA polymerase II C-terminal domain binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1217620

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

5

16

High-throughput

0.925

High

976096

RPB7
DNA-directed RNA polymerase II subunit RPB7

5

5

High-throughput

0.718

High

1217605

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

14

High-throughput

0.691

High

1217626

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

3

High-throughput

0.675

High

130498

SPT5H
Transcription elongation factor SPT5

3

6

High-throughput

0.667

High

912188

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

2

High-throughput

0.650

High

372264

MYC
Myc proto-oncogene protein

3

12

High-throughput

0.633

High

537317

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.628

High

681834

RBTN2
Rhombotin-2

2

11

High-throughput

0.628

High

326342

SCAF4
SR-related and CTD-associated factor 4

1

8

High-throughput

0.618

High

667333

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

10

High-throughput

0.618

High

983664

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

2

High-throughput

0.611

High

588894

RFA2
Replication protein A 32 kDa subunit

2

8

High-throughput

0.584

High

695675

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

7

High-throughput

0.584

High

768396

RFA3
Replication protein A 14 kDa subunit

2

6

High-throughput

0.584

High

1217593

SLX4
Structure-specific endonuclease subunit SLX4

2

13

High-throughput

0.584

High

1217633

PFD2
Prefoldin subunit 2

2

2

High-throughput

0.584

High

1217640

STRAP
Serine-threonine kinase receptor-associated protein

2

11

High-throughput

0.574

High

1217628

WWOX
WW domain-containing oxidoreductase

2

3

High-throughput

0.555

High

506014

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

2

2

High-throughput

0.552

High

997778

CSK21
Casein kinase II subunit alpha

1

13

High-throughput

0.550

High

1217609

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

3

High-throughput

0.541

High

192823

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

3

High-throughput

0.536

High

478078

SNRPA
U1 small nuclear ribonucleoprotein A

1

10

High-throughput

0.536

High

480179

RU1C
U1 small nuclear ribonucleoprotein C

1

3

High-throughput

0.536

High

542061

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

574314

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

6

High-throughput

0.536

High

621891

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

3

High-throughput

0.536

High

686823

S10A4
Protein S100-A4

1

5

High-throughput

0.536

High

775143

FUS
RNA-binding protein FUS

1

13

High-throughput

0.536

High

973944

RUXF
Small nuclear ribonucleoprotein F

1

4

High-throughput

0.536

High

1065235

SSRP1
FACT complex subunit SSRP1

1

14

High-throughput

0.536

High

1160158

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

12

High-throughput

0.536

High

1162975

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1217585

CTR9
RNA polymerase-associated protein CTR9 homolog

1

6

High-throughput

0.536

High

1217591

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

2

High-throughput

0.536

High

786660

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

12

Small-scale

0.535

High

1217583

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

2

2

High-throughput

0.533

High

595463

H15
Histone H1.5

1

3

High-throughput

0.515

High

570906

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

1066673

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.513

High

1217597

LEO1
RNA polymerase-associated protein LEO1

1

0

High-throughput

0.513

High

967797

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

12

Small-scale

0.508

High

347094

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.489

High

445199

S10A6
Protein S100-A6

1

5

High-throughput

0.489

High

506959

POTEI
POTE ankyrin domain family member I

1

9

High-throughput

0.489

High

540254

SPTB1
Spectrin beta chain, erythrocytic

1

8

High-throughput

0.489

High

706161

S10A2
Protein S100-A2

1

5

High-throughput

0.489

High

930925

HSP72
Heat shock-related 70 kDa protein 2

1

4

High-throughput

0.489

High

1123931

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.489

High

1217642

RPKL1
Ribosomal protein S6 kinase-like 1

1

5

High-throughput

0.489

High

1217601

RENT1
Regulator of nonsense transcripts 1

1

0

High-throughput

0.486

High

227586

SPOP
Speckle-type POZ protein

1

3

Small-scale

0.481

High

165045

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

10

High-throughput

0.479

High

172920

XPO1
Exportin-1

1

10

High-throughput

0.479

High

180308

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

10

High-throughput

0.479

High

190950

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

10

High-throughput

0.479

High

239584

MED14
Mediator of RNA polymerase II transcription subunit 14

1

12

High-throughput

0.479

High

260067

BRD4
Bromodomain-containing protein 4

1

10

High-throughput

0.479

High

262523

MCE1
mRNA-capping enzyme

1

5

High-throughput

0.479

High

287456

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

2

High-throughput

0.479

High

316292

RECQ5
ATP-dependent DNA helicase Q5

1

14

High-throughput

0.479

High

316394

RMP
Unconventional prefoldin RPB5 interactor 1

1

2

High-throughput

0.479

High

339991

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

10

High-throughput

0.479

High

430626

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

2

High-throughput

0.479

High

520116

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

558193

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

621660

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

10

High-throughput

0.479

High

711647

3MG
DNA-3-methyladenine glycosylase

1

1

Small-scale

0.479

High

722984

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

11

High-throughput

0.479

High

787751

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

7

High-throughput

0.479

High

830896

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

854869

RECQ1
ATP-dependent DNA helicase Q1

1

12

High-throughput

0.479

High

862208

YAP1
Transcriptional coactivator YAP1

1

18

High-throughput

0.479

High

912068

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

2

High-throughput

0.479

High

923501

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

2

High-throughput

0.479

High

958965

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

3

High-throughput

0.479

High

979804

H4
Histone H4

1

5

High-throughput

0.479

High

1008765

RED1
Double-stranded RNA-specific editase 1

1

6

High-throughput

0.479

High

1045385

TF65
Transcription factor p65

1

6

High-throughput

0.479

High

1096715

RFA4
Replication protein A 30 kDa subunit

1

8

High-throughput

0.479

High

1108351

MED21
Mediator of RNA polymerase II transcription subunit 21

1

1

High-throughput

0.479

High

1128023

DHX8
ATP-dependent RNA helicase DHX8

1

3

High-throughput

0.479

High

1129620

MDC1
Mediator of DNA damage checkpoint protein 1

1

17

High-throughput

0.479

High

1151254

MED1
Mediator of RNA polymerase II transcription subunit 1

1

10

High-throughput

0.479

High

1217587

SPT6H
Transcription elongation factor SPT6

1

4

High-throughput

0.479

High

1217589

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

4

High-throughput

0.479

High

1217590

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1217592

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

1217594

SIR6
NAD-dependent protein deacylase sirtuin-6

1

10

High-throughput

0.479

High

1217600

HDAC2
Histone deacetylase 2

1

7

High-throughput

0.479

High

1217602

DCPS
m7GpppX diphosphatase

1

3

High-throughput

0.479

High

1217607

MED10
Mediator of RNA polymerase II transcription subunit 10

1

2

High-throughput

0.479

High

1217608

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

1217610

WWTR1
WW domain-containing transcription regulator protein 1

1

16

High-throughput

0.479

High

1217614

SFR19
Splicing factor, arginine/serine-rich 19

1

18

High-throughput

0.479

High

1217616

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

11

High-throughput

0.479

High

1217618

GPN1
GPN-loop GTPase 1

1

5

High-throughput

0.479

High

1217619

MED4
Mediator of RNA polymerase II transcription subunit 4

1

2

High-throughput

0.479

High

1217623

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

2

High-throughput

0.479

High

1217624

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

11

High-throughput

0.479

High

1217627

AATF
Protein AATF

1

1

High-throughput

0.479

High

1217629

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

7

High-throughput

0.479

High

1217631

UXT
Protein UXT

1

2

High-throughput

0.479

High

1217632

ZRAN1
Ubiquitin thioesterase ZRANB1

1

13

High-throughput

0.479

High

1217636

NUP50
Nuclear pore complex protein Nup50

1

4

High-throughput

0.479

High

1217637

FBW1A
F-box/WD repeat-containing protein 1A

1

9

High-throughput

0.479

High

1217639

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

7

High-throughput

0.479

High

1217641

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

5

High-throughput

0.479

High

880929

MTR1B
Melatonin receptor type 1B

1

1

High-throughput

0.464

High

48971

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.458

High

335999

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.458

High

1217584

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.458

High

1217603

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

High-throughput

0.458

High

1217611

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.458

High

1217615

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.458

High

1217622

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.458

High

430021

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

106091

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

241947

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.437

High

323420

TRI37
E3 ubiquitin-protein ligase TRIM37

1

12

High-throughput

0.437

High

375599

RASK
GTPase KRas

1

9

High-throughput

0.437

High

412072

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

986477

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

6

High-throughput

0.437

High

995637

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.437

High

1217586

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

1217588

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.437

High

1217596

SP7
Transcription factor Sp7

1

5

High-throughput

0.437

High

1217598

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.437

High

1217604

DAA10
Dynein axonemal assembly factor 10

1

2

High-throughput

0.437

High

1217606

B9D2
B9 domain-containing protein 2

1

1

High-throughput

0.437

High

1217612

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.437

High

1217613

RPAP3
RNA polymerase II-associated protein 3

1

11

High-throughput

0.437

High

1217621

PDRG1
p53 and DNA damage-regulated protein 1

1

2

High-throughput

0.437

High

1217625

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.437

High

1217630

PHRF1
PHD and RING finger domain-containing protein 1

1

19

High-throughput

0.437

High

1217634

GPN3
GPN-loop GTPase 3

1

5

High-throughput

0.437

High

1217635

XPO7
Exportin-7

1

6

High-throughput

0.437

High

1217638

NINL
Ninein-like protein

1

9

High-throughput

0.437

High

1217595

S35G3
Solute carrier family 35 member G3

1

1

High-throughput

0.407

High

1217617

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.407

High

1217599

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.249

Low

731859

CEAM8
Cell adhesion molecule CEACAM8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025