Protein: PCF11
Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11)

Gene: PCF11
Organism: Homo sapiens
Interactions: 86
UniProt ID: O94913

Gene Ontology (top 5):
GO:0000993 - RNA polymerase II complex binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

321866

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

2

4

Small-scale

0.799

High

321829

MAGAB
Melanoma-associated antigen 11

2

1

Small-scale

0.660

High

321879

CARF
CDKN2A-interacting protein

2

1

High-throughput

0.628

High

321822

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

Small-scale

0.618

High

321817

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.584

High

321824

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

2

High-throughput

0.584

High

321826

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

321876

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

5

High-throughput

0.575

High

321806

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

321811

SNRPA
U1 small nuclear ribonucleoprotein A

1

3

High-throughput

0.536

High

321814

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

321816

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

321820

USF1
Upstream stimulatory factor 1

1

4

High-throughput

0.536

High

321823

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.536

High

321827

FUS
RNA-binding protein FUS

1

8

High-throughput

0.536

High

321830

CDK8
Cyclin-dependent kinase 8

1

3

High-throughput

0.536

High

321837

SSRP1
FACT complex subunit SSRP1

1

3

High-throughput

0.536

High

321839

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

321841

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.536

High

321845

SAMD1
Sterile alpha motif domain-containing protein 1

1

2

High-throughput

0.536

High

321884

TNPO3
Transportin-3

1

2

High-throughput

0.536

High

321810

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.515

High

128364

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

High-throughput

0.513

High

321805

KAD1
Adenylate kinase isoenzyme 1

1

0

High-throughput

0.513

High

321833

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

321842

PEA15
Astrocytic phosphoprotein PEA-15

1

0

High-throughput

0.513

High

321854

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.513

High

321869

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

321873

PHAX
Phosphorylated adapter RNA export protein

1

0

High-throughput

0.513

High

321835

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.501

High

321883

ANR50
Ankyrin repeat domain-containing protein 50

1

3

High-throughput

0.489

High

128687

MEN1
Menin

1

1

High-throughput

0.479

High

130337

SPT5H
Transcription elongation factor SPT5

1

2

High-throughput

0.479

High

259240

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

262462

MCE1
mRNA-capping enzyme

1

2

High-throughput

0.479

High

321807

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

321808

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

321809

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

321812

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

3

High-throughput

0.479

High

321813

ANDR
Androgen receptor

1

7

High-throughput

0.479

High

321815

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

321818

GATA1
Erythroid transcription factor

1

3

High-throughput

0.479

High

321819

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

321821

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

3

High-throughput

0.479

High

321828

IF4A3
Eukaryotic initiation factor 4A-III

1

2

High-throughput

0.479

High

321831

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.479

High

321832

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

321836

EWS
RNA-binding protein EWS

1

17

High-throughput

0.479

High

321838

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

2

High-throughput

0.479

High

321840

DHX8
ATP-dependent RNA helicase DHX8

1

3

High-throughput

0.479

High

321846

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

321847

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

Small-scale

0.479

High

321849

THOC4
THO complex subunit 4

1

6

Small-scale

0.479

High

321852

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

321853

SRRM1
Serine/arginine repetitive matrix protein 1

1

4

High-throughput

0.479

High

321855

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

321857

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

4

Small-scale

0.479

High

321859

SP7
Transcription factor Sp7

1

10

High-throughput

0.479

High

321860

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

321862

CNOT9
CCR4-NOT transcription complex subunit 9

1

1

High-throughput

0.479

High

321863

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

321864

SYMPK
Symplekin

1

1

High-throughput

0.479

High

321865

CELF1
CUGBP Elav-like family member 1

1

1

High-throughput

0.479

High

321870

VRK1
Serine/threonine-protein kinase VRK1

1

2

High-throughput

0.479

High

321875

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

1

High-throughput

0.479

High

321877

RNC
Ribonuclease 3

1

2

High-throughput

0.479

High

321878

DJC17
DnaJ homolog subfamily C member 17

1

3

High-throughput

0.479

High

321880

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

321881

NXF1
Nuclear RNA export factor 1

1

1

High-throughput

0.479

High

321882

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

316706

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.458

High

321834

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

321843

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.458

High

321844

AXDN1
Axonemal dynein light chain domain-containing protein 1

1

0

High-throughput

0.458

High

321848

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

321850

WDR75
WD repeat-containing protein 75

1

0

High-throughput

0.458

High

321858

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

321861

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

321871

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

321872

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

321825

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

321851

DHX40
Probable ATP-dependent RNA helicase DHX40

1

3

High-throughput

0.437

High

321856

POC5
Centrosomal protein POC5

1

0

High-throughput

0.426

High

321867

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

321874

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

0

High-throughput

0.249

Low

321868

C170L
Cep170-like protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025