HitPredict

Interactor 1: TBP (P20226)
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)
Gene: TBP

Interactor 2: BRD2 (P25440)
Bromodomain-containing protein 2 (O27.1.1)
Gene: BRD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	35271311, 31753913, 17111193
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0007283 - spermatogenesis
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 339 Hs			1 801
+	Hs
		589845 TBP_HUMAN (1-339): 7.86e-144: 411: 100.00		EP300_HUMAN (31-183): 5.52e-39: 159: 30.72
+	Hs
		589777 TBP_HUMAN (1-339): 7.86e-144: 411: 100.00		TAF1_HUMAN (64-263): 1.16e-16: 87.2: 16.00
+	Sc
		527033 TBP_YEAST (120-337): 9.51e-102: 301: 69.73		RSC1_YEAST (75-483): 9.46e-42: 166: 17.03
+	Sc
		527049 TBP_YEAST (120-337): 9.51e-102: 301: 69.73		GCN5_YEAST (275-456): 2.99e-40: 155: 26.63
+	Sc
		527066 TBP_YEAST (120-337): 9.51e-102: 301: 69.73		RSC2_YEAST (332-725): 2.08e-31: 133: 18.48
+	Sc
		526993 TBP_YEAST (120-337): 9.51e-102: 301: 69.73		BDF1_YEAST (16-240): 5.3e-20: 97.2: 22.47
+	Hs
		600118 TBPL1_HUMAN (155-338): 4.89e-77: 235: 40.22		TAF1_HUMAN (64-263): 1.16e-16: 87.2: 16.00