HitPredict

Interactor 1: CCNA2 (P20248)
Cyclin-A2 (Cyclin-A) (Cyclin A)
Gene: CCNA2

Interactor 2: CDC6 (Q99741)
Cell division control protein 6 homolog (CDC6-related protein) (Cdc18-related protein) (HsCdc18) (p62(cdc6)) (HsCDC6)
Gene: CDC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	9889196, 9566895, 10339564
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048146 - positive regulation of fibroblast proliferation and 1 others more... GO:0051301 - cell division
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 432 Hs			1 560
+	Hs
		538599 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CDC6_HUMAN (1-560): 1.83e-166: 486: 100.00
+	Hs
		590177 CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Hs
		943785 CCNA1_HUMAN (15-432): 7.29e-131: 386: 46.46		ORC1_HUMAN (4-548): 3.74e-94: 308: 22.62
+	Xl
		936141 Q66J45_XENLA (10-432): 1.49e-117: 351: 46.90		P70049_XENLA (2-548): 1.74e-90: 298: 23.70
+	Sp
		500275 CG23_SCHPO (2-429): 6.88e-113: 341: 24.94		CDC18_SCHPO (9-552): 5.47e-83: 271: 25.47
+	Sp
		737066 CG22_SCHPO (66-424): 2.93e-99: 304: 27.90		CDC18_SCHPO (9-552): 5.47e-83: 271: 25.47
+	Sc
		447783 CG22_YEAST (11-432): 2.67e-99: 307: 25.65		CDC6_YEAST (82-521): 6.22e-61: 211: 24.54