Protein: CWC21
Pre-mRNA-splicing factor CWC21 (Complexed with CEF1 protein 21)

Gene: CWC21
Organism: Saccharomyces cerevisiae S288C
Interactions: 70
UniProt ID: Q03375

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0005684 - U2-type spliceosomal complex
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

780215

SN114
Pre-mRNA-splicing factor SNU114

2

0

Small-scale

0.716

High

1042529

CEF1
Pre-mRNA-splicing factor CEF1

5

0

Small-scale

0.679

High

751780

PRP8
Pre-mRNA-splicing factor 8

3

0

Small-scale

0.633

High

1042540

CWC2
Pre-mRNA-splicing factor CWC2

3

0

Small-scale

0.628

High

1042542

PRP46
Pre-mRNA-splicing factor PRP46

3

0

Small-scale

0.622

High

739193

PRP19
Pre-mRNA-processing factor 19

3

0

High-throughput

0.616

High

817153

RSMB
Small nuclear ribonucleoprotein-associated protein B

3

0

Small-scale

0.613

High

1042538

NCBP2
Nuclear cap-binding protein subunit 2

3

0

High-throughput

0.613

High

1042539

RU2A
U2 small nuclear ribonucleoprotein A'

3

0

Small-scale

0.613

High

1042533

SN309
Pre-mRNA-splicing factor SNT309

3

0

Small-scale

0.606

High

1042541

CLF1
Pre-mRNA-splicing factor CLF1

2

2

High-throughput

0.601

High

664616

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

2

2

Small-scale

0.595

High

744155

BRR2
Pre-mRNA-splicing helicase BRR2

2

1

Small-scale

0.584

High

933134

RUXF
Small nuclear ribonucleoprotein F

2

1

Small-scale

0.584

High

625123

PRP9
Pre-mRNA-splicing factor PRP9

2

0

High-throughput

0.576

High

1037749

CUS1
Cold sensitive U2 snRNA suppressor 1

2

0

High-throughput

0.576

High

638079

ISY1
Pre-mRNA-splicing factor ISY1

2

0

Small-scale

0.559

High

672071

BUD31
Pre-mRNA-splicing factor BUD31

2

0

Small-scale

0.559

High

700139

PRP45
Pre-mRNA-processing protein 45

2

0

Small-scale

0.559

High

702277

YJU2
Splicing factor YJU2

2

0

Small-scale

0.559

High

739269

PRP21
Pre-mRNA-splicing factor PRP21

2

0

Small-scale

0.559

High

829954

PRP17
Pre-mRNA-processing factor 17

2

0

Small-scale

0.559

High

847824

SMD3
Small nuclear ribonucleoprotein Sm D3

2

0

Small-scale

0.559

High

919216

SYF2
Pre-mRNA-splicing factor SYF2

2

0

Small-scale

0.559

High

1036170

SMD1
Small nuclear ribonucleoprotein Sm D1

2

0

Small-scale

0.559

High

1037089

SPP2
Pre-mRNA-splicing factor SPP2

2

0

Small-scale

0.559

High

1042534

SMD2
Small nuclear ribonucleoprotein Sm D2

2

0

Small-scale

0.559

High

726176

2AAA
Protein phosphatase PP2A regulatory subunit A

1

1

High-throughput

0.536

High

628226

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

2

2

High-throughput

0.533

High

1042537

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.493

High

558849

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.486

High

579969

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

590219

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

2

High-throughput

0.479

High

625043

PRP6
Pre-mRNA-splicing factor 6

1

2

Small-scale

0.479

High

820832

RUXG
Small nuclear ribonucleoprotein G

1

1

Small-scale

0.479

High

865281

LSM8
LSM2-LSM8 complex subunit LSM8

1

1

Small-scale

0.479

High

892780

SF3B1
U2 snRNP component HSH155

1

1

High-throughput

0.479

High

1042531

SYF1
Pre-mRNA-splicing factor SYF1

1

2

High-throughput

0.479

High

1042535

LSM6
LSM complex subunit LSM6

1

1

Small-scale

0.479

High

1027266

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.460

High

444612

DED1
ATP-dependent RNA helicase DED1

1

0

Small-scale

0.458

High

757526

NCBP1
Nuclear cap-binding protein complex subunit 1

1

0

High-throughput

0.458

High

781583

NTR2
Pre-mRNA-splicing factor NTR2

1

0

Small-scale

0.458

High

796459

SLT11
Pre-mRNA-splicing factor SLT11

1

0

High-throughput

0.458

High

797685

NTC20
Pre-mRNA-splicing factor NTC20

1

0

High-throughput

0.458

High

818482

LSM5
LSM complex subunit LSM5

1

0

Small-scale

0.458

High

863093

CWC26
Pre-mRNA-splicing factor CWC26

1

0

High-throughput

0.458

High

919727

CWC22
Pre-mRNA-splicing factor CWC22

1

0

High-throughput

0.458

High

923933

CWC25
Pre-mRNA-splicing factor CWC25

1

0

High-throughput

0.458

High

1031038

NOP3
Serine/arginine

1

0

Small-scale

0.458

High

1038535

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.458

High

1042530

CWC15
Pre-mRNA-splicing factor CWC15

1

0

High-throughput

0.458

High

1042532

RSE1
Pre-mRNA-splicing factor RSE1

1

0

High-throughput

0.458

High

393240

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

524973

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

527539

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

546063

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

739452

ZUO1
Zuotin

1

1

High-throughput

0.445

High

742274

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

819640

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

671696

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.426

High

752666

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

804412

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

810754

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.426

High

914880

CWC23
Pre-mRNA-splicing factor CWC23

1

0

High-throughput

0.426

High

823292

JEM1
DnaJ-like chaperone JEM1

1

1

High-throughput

0.407

High

918058

SCW11
Probable family 17 glucosidase SCW11

1

0

High-throughput

0.265

Low

626870

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.261

Low

811378

CAJ1
Protein CAJ1

1

0

High-throughput

0.232

Low

1042536

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025