HitPredict

Interactor 1: KPCA (P20444)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: Prkca

Interactor 2: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	12881490
Identification Methods	coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	C1_1~SH2, C2~SH2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 672 Mm			1 217
+	Hs
		408528 KPCB_HUMAN (1-664): 0: 740: 77.99		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Mm
		411915 KPCE_MOUSE (8-664): 0: 625: 44.91		LCK_MOUSE (3-202): 5.14e-38: 139: 28.44
+	Mm
		403411 KPCE_MOUSE (8-664): 0: 625: 44.91		SRC_MOUSE (80-215): 1.5e-10: 61.9: 17.24
+	Hs
		681710 AKT1_HUMAN (224-661): 7.71e-156: 460: 36.48		CSK_HUMAN (2-139): 4.25e-24: 100: 36.24
+	Hs
		681838 AKT1_HUMAN (224-661): 7.71e-156: 460: 36.48		PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93
+	Hs
		412046 AKT1_HUMAN (224-661): 7.71e-156: 460: 36.48		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		433609 AKT2_HUMAN (224-661): 3.19e-157: 463: 38.16		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Mm
		403418 AKT1_MOUSE (224-661): 1.84e-156: 461: 36.48		SRC_MOUSE (80-215): 1.5e-10: 61.9: 17.24
+	Hs
		522810 AKT1_HUMAN (224-661): 7.71e-156: 460: 36.48		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		522780 KS6B1_HUMAN (261-669): 1.63e-153: 455: 35.25		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		433578 KS6B1_HUMAN (261-669): 1.63e-153: 455: 35.25		LYN_HUMAN (136-215): 4.12e-10: 60.7: 24.39
+	Hs
		411685 KPCT_HUMAN (7-243): 9.68e-56: 203: 29.84		LCK_HUMAN (3-202): 7.66e-38: 138: 28.91
+	Hs
		337439 KPCD_HUMAN (9-164): 6.14e-57: 206: 39.76		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Mm
		654978 KPCT_MOUSE (7-238): 1.26e-57: 209: 30.86		VAV_MOUSE (3-60): 1.12e-15: 76.9: 43.10
+	Hs
		548689 KPCT_HUMAN (7-243): 9.68e-56: 203: 29.84		VAV_HUMAN (3-60): 1.14e-15: 76.9: 43.10
+	Hs
		412145 KPCD_HUMAN (9-164): 6.14e-57: 206: 39.76		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		412141 KPCT_HUMAN (7-243): 9.68e-56: 203: 29.84		FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58
+	Hs
		522929 KPCD_HUMAN (9-164): 6.14e-57: 206: 39.76		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03
+	Hs
		337438 KPCZ_HUMAN (61-204): 2.36e-14: 78.5: 17.95		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		522928 KPCZ_HUMAN (61-204): 2.36e-14: 78.5: 17.95		SRC_HUMAN (160-215): 1.74e-10: 61.9: 31.03