HitPredict

Interactor 1: NEBU (P20929)
Nebulin
Gene: NEB

Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.716

Property	Details
Experiments	12482578
Identification Methods	classical fluorescence spectroscopy, circular dichroism, nuclear magnetic resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_9, RhoGEF~SH3_9
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 8525 Hs			1 1333
+	Hs
		992493 PACN1_HUMAN (8092-8525): 5.92e-65: 232: 15.91		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		992476 SPTN1_HUMAN (7876-8525): 2.1e-58: 229: 11.33		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		992496 ITSN2_HUMAN (7807-8525): 5.36e-55: 217: 9.77		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		992502 PACN3_HUMAN (8077-8525): 1.03e-57: 210: 11.84		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		992477 ITSN1_HUMAN (7577-8524): 1.01e-46: 190: 11.23		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Rn
		88907 PACN1_RAT (8077-8525): 1.16e-55: 205: 15.79		D4A3T0_RAT (1-1333): 0: 958: 96.40
+	Hs
		992492 SRBS1_HUMAN (8368-8525): 5.41e-27: 125: 20.23		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		992521 ITSN2_HUMAN (7807-8525): 5.36e-55: 217: 9.77		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		992523 PACN3_HUMAN (8077-8525): 1.03e-57: 210: 11.84		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		992508 ITSN1_HUMAN (7577-8524): 1.01e-46: 190: 11.23		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		1078876 ITSN1_HUMAN (7577-8524): 1.01e-46: 190: 11.23		PREX1_HUMAN (194-567): 2.78e-94: 337: 21.98
+	Hs
		224714 SPTN1_HUMAN (7876-8525): 2.1e-58: 229: 11.33		KALRN_HUMAN (8-625): 2.16e-64: 244: 12.85
+	Mm
		57809 B9EKJ1_MOUSE (7538-8525): 3.16e-57: 225: 10.74		KALRN_MOUSE (8-594): 7.63e-64: 242: 13.53
+	Mm
		57827 SPTN1_MOUSE (7538-8525): 3.86e-57: 225: 10.74		KALRN_MOUSE (8-594): 7.63e-64: 242: 13.53
+	Hs
		279897 ITSN2_HUMAN (7807-8525): 5.36e-55: 217: 9.77		TRIO_HUMAN (101-691): 1.18e-59: 229: 12.83
+	Hs
		305112 RIMB1_HUMAN (8322-8525): 9.36e-10: 68.5: 15.96		RPGF4_HUMAN (465-1021): 1.66e-84: 300: 15.94
+	Hs
		1203939 SH3R3_HUMAN (8343-8525): 1.76e-15: 87: 18.62		RGPS2_HUMAN (774-1100): 6.56e-79: 274: 23.67
+	Mm
		57854 SRBS1_MOUSE (8246-8525): 5.99e-23: 111: 14.24		KALRN_MOUSE (8-594): 7.63e-64: 242: 13.53