Interactor 1: CAN3 (P20807)
Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1)
Gene: CAPN3

Interactor 2: CAN3 (P20807)
Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1)
Gene: CAPN3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.849

The method score is based on:

Property Details
Experiments 32296183, unassigned1304, 24846670
Identification Methods two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, x-ray crystallography
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Calpain_III~EF-hand_8, Calpain_III~Peptidase_C2, EF-hand_6~EF-hand_6, EF-hand_6~EF-hand_8, EF-hand_8~EF-hand_8, Peptidase_C2~Peptidase_C2
Common GO terms GO:0003824 - catalytic activity
GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005634 - nucleus
GO:0005730 - nucleolus
and 43 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 821
Hs

1 821
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Hs
+ Hs
+ Hs
+ Rn
+ Zm
+ At

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Last updated: 15 Jul 2024