HitPredict

Interactor 1: FILA (P20930)
Filaggrin
Gene: FLG

Interactor 2: TXNIP (Q9H3M7)
Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
Gene: TXNIP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31669268
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0030216 - keratinocyte differentiation
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 4061 Hs			1 391
+	Hs
		1206196 HORN_HUMAN (2054-4025): 1.48e-58: 228: 17.22		TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00
+	Hs
		380861 S100B_HUMAN (1-92): 9.63e-46: 162: 34.78		TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00
+	Hs
		642992 S10A4_HUMAN (3-102): 8.89e-44: 157: 26.00		TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00
+	Dm
		65654 CO4A1_DROME (94-852): 2.42e-56: 220: 8.59		A8JQV1_DROME (10-353): 2.34e-101: 308: 16.54
+	Dm
		435979 CO4A1_DROME (94-852): 2.42e-56: 220: 8.59		Q4V467_DROME (10-353): 1.91e-80: 252: 14.10
+	Dm
		435985 CO4A1_DROME (94-852): 2.42e-56: 220: 8.59		Q9VHZ7_DROME (10-301): 2.68e-77: 249: 22.15
+	Dm
		65689 Q9VMV5_DROME (119-503): 1.42e-23: 113: 8.86		A8JQV1_DROME (10-353): 2.34e-101: 308: 16.54
+	Dm
		1367621 Q9VMV5_DROME (119-503): 1.42e-23: 113: 8.86		Q9VI00_DROME (8-379): 1.03e-93: 289: 21.91
+	Dm
		1118491 Q9VMV5_DROME (119-503): 1.42e-23: 113: 8.86		Q4V467_DROME (10-353): 1.91e-80: 252: 14.10
+	Dm
		1367601 Q9VMV5_DROME (119-503): 1.42e-23: 113: 8.86		Q9VHZ7_DROME (10-301): 2.68e-77: 249: 22.15
+	Hs
		416363 S10A9_HUMAN (1-102): 2.02e-40: 148: 35.92		ARRB2_HUMAN (15-323): 2.03e-60: 202: 12.18
+	Hs
		416383 S10A9_HUMAN (1-102): 2.02e-40: 148: 35.92		ARRB1_HUMAN (25-358): 2.59e-56: 191: 12.95