HitPredict

Interactor 1: AT2A2 (P16615)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
Gene: ATP2A2

Interactor 2: PPLA (P26678)
Phospholamban (PLB)
Gene: PLN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.935

The method score is based on:

Property Details
Experiments 31046837, 28890335, 11854448, 39261533, 12032137, 10809745
Identification Methods affinity chromatography technology, pull down, fluorescent resonance energy transfer
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Cation_ATPase_C~Phospholamban
Common GO terms GO:0002026 - regulation of the force of heart contraction
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006874 - intracellular calcium ion homeostasis
GO:0016020 - membrane
and 6 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 1042
Hs

1 52
+ Mm
+ Oc
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025