HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35235311
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~CH, CH~Filamin, Filamin~Filamin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0030018 - Z disc and 1 others more... GO:0051015 - actin filament binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 2725
+	Hs
		261262 FLNB_HUMAN (28-2647): 0: 2710: 69.63		FLNC_HUMAN (1-2725): 0: 2507: 100.00
+	Hs
		597957 FLNA_HUMAN (1-2647): 0: 2776: 100.00		FLNA_HUMAN (167-2725): 0: 1226: 35.27
+	Hs
		261201 FLNA_HUMAN (1-2647): 0: 2776: 100.00		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Hs
		1052874 FLNC_HUMAN (32-2647): 0: 1432: 35.96		FLNC_HUMAN (1-2725): 0: 2507: 100.00
+	Hs
		261164 FLNB_HUMAN (28-2647): 0: 2710: 69.63		FLNB_HUMAN (146-2725): 0: 1198: 35.18
+	Hs
		211497 FLNA_HUMAN (1-2647): 0: 2776: 100.00		ACTN4_HUMAN (16-387): 7.58e-120: 406: 26.68
+	Hs
		598070 FLNA_HUMAN (1-2647): 0: 2776: 100.00		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		362811 FLNA_HUMAN (1-2647): 0: 2776: 100.00		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Hs
		261173 FLNB_HUMAN (28-2647): 0: 2710: 69.63		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Hs
		598253 FLNA_HUMAN (1-2647): 0: 2776: 100.00		TITIN_HUMAN (1554-2636): 3.13e-09: 65.5: 10.78
+	Dm
		1181837 Q7KSF4_DROME (30-2420): 0: 1442: 36.24		FLNA_DROME (758-2724): 0: 1012: 33.19
+	Hs
		363145 FLNC_HUMAN (32-2647): 0: 1432: 35.96		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83
+	Rn
		1167662 Q6XD99_RAT (22-460): 2.17e-118: 423: 24.62		ACTN1_RAT (13-382): 7.06e-123: 414: 26.30
+	Hs
		521485 ACTN2_HUMAN (6-459): 1.76e-121: 410: 23.62		ACTN1_HUMAN (13-382): 6.48e-123: 414: 26.30
+	Hs
		725624 ACTN2_HUMAN (6-459): 1.76e-121: 410: 23.62		ACTN2_HUMAN (2-387): 2.32e-122: 412: 26.00
+	Hs
		963291 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		363087 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		FINC_HUMAN (1545-2724): 1.85e-65: 250: 13.83