HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: SH2B3 (Q9UQQ2)
SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)
Gene: SH2B3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	11163396
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035855 - megakaryocyte development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2647 Hs			1 575
+	Hs
		522770 FLNA_HUMAN (1-2647): 0: 2776: 100.00		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Hs
		598047 FLNA_HUMAN (1-2647): 0: 2776: 100.00		GRB2_HUMAN (307-547): 8.13e-46: 162: 12.86
+	Hs
		580922 FLNA_HUMAN (1-2647): 0: 2776: 100.00		PLCG1_HUMAN (348-575): 7.81e-20: 96.2: 14.96
+	Hs
		261240 FLNB_HUMAN (28-2647): 0: 2710: 69.63		GRB2_HUMAN (307-547): 8.13e-46: 162: 12.86
+	Mm
		1207250 FLNA_MOUSE (1-2647): 0: 2784: 97.32		PLCG2_MOUSE (337-496): 6.52e-16: 83.5: 24.26
+	Hs
		261193 FLNB_HUMAN (28-2647): 0: 2710: 69.63		NCK1_HUMAN (286-446): 2.61e-38: 147: 18.39
+	Hs
		261197 FLNB_HUMAN (28-2647): 0: 2710: 69.63		PLCG1_HUMAN (348-575): 7.81e-20: 96.2: 14.96
+	Hs
		924572 FLNC_HUMAN (32-2647): 0: 1432: 35.96		GRB2_HUMAN (307-547): 8.13e-46: 162: 12.86
+	Hs
		557690 FLNC_HUMAN (32-2647): 0: 1432: 35.96		NCK1_HUMAN (286-446): 2.61e-38: 147: 18.39
+	Hs
		581006 FLNC_HUMAN (32-2647): 0: 1432: 35.96		PLCG1_HUMAN (348-575): 7.81e-20: 96.2: 14.96
+	Ce
		87661 D0IMZ5_CAEEL (860-2646): 1.96e-170: 585: 22.03		Q95PW9_CAEEL (242-464): 8.33e-39: 148: 21.43
+	Hs
		924482 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		GRB2_HUMAN (307-547): 8.13e-46: 162: 12.86
+	Hs
		521454 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Hs
		521521 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		GRB2_HUMAN (307-547): 8.13e-46: 162: 12.86
+	Hs
		211480 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Hs
		666072 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		SHC1_HUMAN (350-453): 1.1e-29: 125: 34.62
+	Hs
		211557 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		GRB2_HUMAN (307-547): 8.13e-46: 162: 12.86
+	Hs
		129277 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		P85B_HUMAN (329-463): 2.73e-18: 90.9: 18.38
+	Hs
		211506 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		SHC1_HUMAN (350-453): 1.1e-29: 125: 34.62
+	Mm
		1143722 SPTB2_MOUSE (22-460): 2.2e-118: 423: 24.62		PLCG2_MOUSE (337-496): 6.52e-16: 83.5: 24.26