HitPredict

Interactor 1: VDAC1 (P21796)
Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)
Gene: VDAC1

Interactor 2: HXK2 (P52789)
Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase)
Gene: HK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	32021252, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0016020 - membrane GO:2000378 - negative regulation of reactive oxygen species metabolic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 283 Hs			1 917
+	Rn
		654991 VDAC1_RAT (1-283): 2.26e-110: 322: 98.59		HXK2_RAT (1-917): 0: 1365: 94.44
+	Hs
		856259 VDAC3_HUMAN (1-283): 1.29e-105: 310: 67.49		HXK2_HUMAN (1-917): 0: 1376: 100.00
+	Hs
		583285 VDAC1_HUMAN (1-283): 1.37e-110: 322: 100.00		HXK1_HUMAN (1-915): 0: 1347: 73.55
+	Hs
		583383 VDAC3_HUMAN (1-283): 1.29e-105: 310: 67.49		HXK1_HUMAN (1-915): 0: 1347: 73.55
+	Rn
		404410 VDAC1_RAT (1-283): 2.26e-110: 322: 98.59		HXK1_RAT (453-913): 0: 566: 53.13
+	At
		1114896 VDAC1_ARATH (1-282): 7.78e-84: 254: 21.75		HXK1_ARATH (22-465): 0: 536: 34.13