Protein: EPHB4
Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)

Gene: EPHB4
Organism: Homo sapiens
Interactions: 153
UniProt ID: P54760

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0002042 - cell migration involved in sprouting angiogenesis
GO:0003007 - heart morphogenesis
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005003 - ephrin receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

914388

EFNB2
Ephrin-B2

6

20

Small-scale

0.949

High

568048

HLAE
HLA class I histocompatibility antigen, alpha chain E

3

9

High-throughput

0.861

High

931961

LRC33
Transforming growth factor beta activator LRRC33

2

17

High-throughput

0.811

High

380272

DRA
HLA class II histocompatibility antigen, DR alpha chain

2

14

High-throughput

0.789

High

931933

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

62105

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

11

High-throughput

0.726

High

931982

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

20

High-throughput

0.726

High

931948

EPHA7
Ephrin type-A receptor 7

1

18

High-throughput

0.715

High

378593

EPO
Erythropoietin

1

0

Small-scale

0.708

High

463931

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.691

High

567821

PRG2
Bone marrow proteoglycan

1

3

High-throughput

0.691

High

593318

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.691

High

688539

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

10

High-throughput

0.691

High

731832

CEAM8
Cell adhesion molecule CEACAM8

1

11

High-throughput

0.691

High

761196

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.691

High

913123

STAT2
Signal transducer and activator of transcription 2

1

11

High-throughput

0.691

High

931826

EPHA5
Ephrin type-A receptor 5

1

16

High-throughput

0.691

High

931944

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

11

High-throughput

0.691

High

931950

CDC37
Hsp90 co-chaperone Cdc37

1

19

High-throughput

0.691

High

931998

CRLF2
Cytokine receptor-like factor 2

1

10

High-throughput

0.691

High

932000

PAR6A
Partitioning defective 6 homolog alpha

1

14

High-throughput

0.691

High

932006

EPHA6
Ephrin type-A receptor 6

1

18

High-throughput

0.691

High

932010

CLC4A
C-type lectin domain family 4 member A

1

8

High-throughput

0.691

High

168393

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

High-throughput

0.656

High

421786

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.647

High

710613

EPHA3
Ephrin type-A receptor 3

1

17

High-throughput

0.646

High

931920

EPHB1
Ephrin type-B receptor 1

1

19

High-throughput

0.646

High

470273

NEP
Neprilysin

2

2

High-throughput

0.628

High

931969

I17RC
Interleukin-17 receptor C

2

2

High-throughput

0.628

High

931974

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

1

High-throughput

0.628

High

931980

MRAP2
Melanocortin-2 receptor accessory protein 2

2

2

High-throughput

0.628

High

932005

P2RX2
P2X purinoceptor 2

2

1

High-throughput

0.628

High

932020

PCDG5
Protocadherin gamma-A5

2

8

High-throughput

0.628

High

932022

PCDC2
Protocadherin alpha-C2

2

6

High-throughput

0.628

High

931951

CL12B
C-type lectin domain family 12 member B

1

6

High-throughput

0.618

High

126523

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

181787

EPHB6
Ephrin type-B receptor 6

1

17

Small-scale

0.618

High

375321

RASK
GTPase KRas

1

20

High-throughput

0.618

High

410734

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.618

High

466172

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

580954

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601222

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

635248

EFNA1
Ephrin-A1

1

20

High-throughput

0.618

High

774234

BASI
Basigin

1

14

High-throughput

0.618

High

840937

ABL2
Tyrosine-protein kinase ABL2

1

20

High-throughput

0.618

High

909990

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

931926

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

931927

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

931928

RAB2A
Ras-related protein Rab-2A

1

13

High-throughput

0.618

High

931930

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

931931

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

931934

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

931938

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

931947

RAB35
Ras-related protein Rab-35

1

13

High-throughput

0.618

High

931949

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

931959

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

931976

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

931994

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

931997

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

931936

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

3

2

High-throughput

0.609

High

931986

ADPGK
ADP-dependent glucokinase

2

0

High-throughput

0.602

High

363032

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.575

High

484088

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.575

High

749318

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

1

High-throughput

0.575

High

931924

TMPS3
Transmembrane protease serine 3

2

17

High-throughput

0.574

High

931943

SG2A2
Mammaglobin-A

2

1

High-throughput

0.574

High

931995

MANS1
MANSC domain-containing protein 1

2

1

High-throughput

0.574

High

931922

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.561

High

931935

TBA1B
Tubulin alpha-1B chain

1

12

High-throughput

0.553

High

931945

PWP1
Periodic tryptophan protein 1 homolog

1

9

High-throughput

0.553

High

931958

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.553

High

931996

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.553

High

437653

HEPS
Serine protease hepsin

1

17

High-throughput

0.536

High

868321

V1BR
Vasopressin V1b receptor

1

2

High-throughput

0.536

High

931921

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

3

High-throughput

0.536

High

931964

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.536

High

931971

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

2

High-throughput

0.536

High

931979

T106A
Transmembrane protein 106A

1

2

High-throughput

0.536

High

931989

TMPSD
Transmembrane protease serine 13

1

18

High-throughput

0.536

High

932009

FBX2
F-box only protein 2

1

8

High-throughput

0.536

High

932011

PCDAC
Protocadherin alpha-12

1

6

High-throughput

0.536

High

932012

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

5

High-throughput

0.536

High

932017

PCDB3
Protocadherin beta-3

1

6

High-throughput

0.536

High

932018

PCDG7
Protocadherin gamma-A7

1

8

High-throughput

0.536

High

932019

PCDG6
Protocadherin gamma-A6

1

8

High-throughput

0.536

High

932021

PCDA8
Protocadherin alpha-8

1

6

High-throughput

0.536

High

932024

ST14
Suppressor of tumorigenicity 14 protein

1

17

High-throughput

0.536

High

932025

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

518824

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.513

High

931977

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

931983

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.513

High

931967

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

1

Small-scale

0.512

High

932015

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

868474

RL29
Large ribosomal subunit protein eL29

1

1

High-throughput

0.500

High

931991

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

1

High-throughput

0.500

High

932013

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

1

High-throughput

0.500

High

286530

SG2A1
Mammaglobin-B

1

1

High-throughput

0.489

High

931955

BRID5
BRICHOS domain-containing protein 5

1

2

High-throughput

0.489

High

931963

NRSN1
Neurensin-1

1

1

High-throughput

0.489

High

931970

RN149
E3 ubiquitin-protein ligase RNF149

1

3

High-throughput

0.489

High

931987

ZSA5A
Zinc finger and SCAN domain-containing protein 5A

1

6

High-throughput

0.489

High

931999

SDF2L
Stromal cell-derived factor 2-like protein 1

1

5

High-throughput

0.489

High

932014

SL9A8
Sodium/hydrogen exchanger 8

1

2

High-throughput

0.489

High

218003

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.479

High

429582

JUN
Transcription factor Jun

1

1

High-throughput

0.479

High

647514

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

Small-scale

0.479

High

910829

IMA1
Importin subunit alpha-1

1

1

Small-scale

0.479

High

931929

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

5

Small-scale

0.479

High

931932

ARF6
ADP-ribosylation factor 6

1

12

High-throughput

0.479

High

931939

CAV1
Caveolin-1

1

7

High-throughput

0.479

High

931940

KMT2A
Histone-lysine N-methyltransferase 2A

1

3

High-throughput

0.479

High

931941

CKAP4
Cytoskeleton-associated protein 4

1

13

High-throughput

0.479

High

931942

KLC1
Kinesin light chain 1

1

2

High-throughput

0.479

High

931946

EI2BA
Translation initiation factor eIF2B subunit alpha

1

4

High-throughput

0.479

High

931956

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

931962

DHX37
Probable ATP-dependent RNA helicase DHX37

1

4

High-throughput

0.479

High

931966

PCD20
Protocadherin-20

1

9

Small-scale

0.479

High

931972

DDX54
ATP-dependent RNA helicase DDX54

1

8

High-throughput

0.479

High

931978

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.479

High

931985

QRFPR
Pyroglutamylated RF-amide peptide receptor

1

3

Small-scale

0.479

High

931988

REPI1
DNA-binding protein REPIN1

1

5

High-throughput

0.479

High

931990

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.479

High

931993

DNJC5
DnaJ homolog subfamily C member 5

1

13

High-throughput

0.479

High

932001

TMPS4
Transmembrane protease serine 4

1

17

High-throughput

0.479

High

932007

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

6

High-throughput

0.479

High

596009

H12
Histone H1.2

1

2

High-throughput

0.470

High

892533

DNLI3
DNA ligase 3

1

0

High-throughput

0.458

High

73789

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

5

High-throughput

0.445

High

388392

B3AT
Band 3 anion transport protein

1

9

High-throughput

0.445

High

466880

ACM4
Muscarinic acetylcholine receptor M4

1

1

High-throughput

0.445

High

876419

EAA4
Excitatory amino acid transporter 4

1

13

High-throughput

0.445

High

896359

ERF
ETS domain-containing transcription factor ERF

1

5

High-throughput

0.445

High

931925

CD81
CD81 antigen

1

3

High-throughput

0.445

High

931953

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.445

High

931957

ZNT10
Calcium/manganese antiporter SLC30A10

1

5

High-throughput

0.445

High

931973

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

5

High-throughput

0.445

High

931975

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.445

High

931952

SE1L2
Protein sel-1 homolog 2

1

3

High-throughput

0.437

High

931960

TMM17
Transmembrane protein 17

1

2

High-throughput

0.437

High

931968

KRI1
Protein KRI1 homolog

1

7

High-throughput

0.437

High

931992

CCD68
Coiled-coil domain-containing protein 68

1

1

Small-scale

0.437

High

932002

RBM28
RNA-binding protein 28

1

10

High-throughput

0.437

High

932003

USE1
Vesicle transport protein USE1

1

2

High-throughput

0.437

High

932008

LEF1
Lymphoid enhancer-binding factor 1

1

2

Small-scale

0.437

High

932016

CHTOP
Chromatin target of PRMT1 protein

1

3

High-throughput

0.437

High

932023

SRPRB
Signal recognition particle receptor subunit beta

1

20

High-throughput

0.437

High

931923

G6PT2
Glucose-6-phosphate exchanger SLC37A1

1

5

High-throughput

0.407

High

931937

DLK1
Protein delta homolog 1

1

9

High-throughput

0.407

High

931984

MF14A
Hippocampus abundant transcript 1 protein

1

9

High-throughput

0.407

High

931981

TECT2
Tectonic-2

2

0

High-throughput

0.328

High

931954

CC137
Coiled-coil domain-containing protein 137

1

0

High-throughput

0.249

Low

931965

GLT16
Polypeptide N-acetylgalactosaminyltransferase 16

1

0

Small-scale

0.249

Low

932004

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025