HitPredict

Interactor 1: FGFR2 (P21802)
Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
Gene: FGFR2

Interactor 2: STA5A (P42229)
Signal transducer and activator of transcription 5A
Gene: STAT5A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	21464042
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 821 Hs			1 794
+	Hs
		601481 FGFR2_HUMAN (1-821): 0: 863: 100.00		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		601474 FGFR2_HUMAN (1-821): 0: 863: 100.00		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		507894 FGFR1_HUMAN (1-820): 0: 772: 71.17		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		849879 EPHA4_HUMAN (18-794): 4.37e-165: 506: 18.60		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		609197 FGFR3_HUMAN (10-821): 0: 731: 65.69		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		499239 KIT_HUMAN (60-803): 1.89e-130: 415: 25.23		STA5A_HUMAN (1-794): 0: 1050: 100.00
+	Hs
		384522 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		499250 KIT_HUMAN (60-803): 1.89e-130: 415: 25.23		STA5B_HUMAN (1-774): 0: 997: 93.84
+	Hs
		776626 EPHA5_HUMAN (18-766): 3.48e-163: 502: 17.53		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Mm
		786524 TIE2_MOUSE (7-763): 2.45e-159: 495: 21.70		STAT3_MOUSE (1-723): 0: 737: 29.94
+	Hs
		384428 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Hs
		434150 RET_HUMAN (228-816): 2.74e-144: 455: 34.26		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		384414 NTRK1_HUMAN (157-765): 4.6e-143: 443: 25.04		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		499238 KIT_HUMAN (60-803): 1.89e-130: 415: 25.23		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Hs
		572594 VGFR1_HUMAN (5-134): 1.03e-11: 70.9: 16.42		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Mm
		729405 VGFR3_MOUSE (42-378): 3.4e-17: 88.7: 17.77		STAT3_MOUSE (1-723): 0: 737: 29.94
+	Hs
		729622 VGFR2_HUMAN (46-363): 1.44e-11: 70.5: 16.82		STAT1_HUMAN (1-724): 0: 755: 28.09
+	Hs
		572592 VGFR1_HUMAN (5-134): 1.03e-11: 70.9: 16.42		STAT3_HUMAN (1-723): 0: 736: 29.94
+	Hs
		729621 VGFR2_HUMAN (46-363): 1.44e-11: 70.5: 16.82		STAT3_HUMAN (1-723): 0: 736: 29.94