Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3
Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.92 | 1.00 | 0.963 |
The method score is based on:
Property | Details |
---|---|
Experiments | 24189400, 8665853, 25315821, 8816440, 10913256, 20007378, 21575594, 23680147 |
Identification Methods | affinity chromatography technology, enzymatic study, two hybrid, pull down, x-ray crystallography, nuclear magnetic resonance, protein kinase assay |
Interaction Type | physical association, direct interaction, phosphorylation reaction |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | Furin-like~Furin-like, Furin-like~GF_recep_IV, Furin-like~Recep_L_domain, GF_recep_IV~GF_recep_IV, GF_recep_IV~Recep_L_domain, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, Recep_L_domain~Recep_L_domain |
Common GO terms | GO:0003197 - endocardial cushion development GO:0004672 - protein kinase activity GO:0004888 - transmembrane signaling receptor activity GO:0005524 - ATP binding GO:0005615 - extracellular space and 42 others more... |
Homologous interactions | 17 |
Homologous interactions
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024