HitPredict

Interactor 1: RYR1 (P21817)
Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
Gene: RYR1

Interactor 2: RYR2 (Q92736)
Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
Gene: RYR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.63 1.00 0.799

The method score is based on:

Property Details
Experiments 14722100, 12213830
Identification Methods pull down, biochemical, affinity chromatography technology
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Ins145_P3_rec~Ins145_P3_rec, Ins145_P3_rec~MIR, Ins145_P3_rec~RIH_assoc, Ins145_P3_rec~RYDR_ITPR, EF-hand_7~Ion_trans, Ion_trans~Ion_trans, Ion_trans~RR_TM4-6, MIR~MIR, MIR~RYDR_ITPR, RR_TM4-6~RR_TM4-6, RYDR_ITPR~RYDR_ITPR, RYDR_ITPR~SPRY, RyR~RyR, RyR~SPRY, SPRY~SPRY
Common GO terms GO:0001666 - response to hypoxia
GO:0005219 - ryanodine-sensitive calcium-release channel activity
GO:0005262 - calcium channel activity
GO:0005509 - calcium ion binding
GO:0005516 - calmodulin binding
and 17 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 5038
Hs

1 4967
+ Mm
+ Hs
+ Mm
+ Hs
+ Oc
+ Hs
+ Hs
+ Hs
+ Mm
+ Rn
+ Hs
+ Ce
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024