HitPredict

Interactor 1: FBRL (P22087)
rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase) (U6 snRNA 2'-O-methyltransferase fibrillarin)
Gene: FBL

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.706

Property	Details
Experiments	29845934, 26186194, 34079125, 33961781, 18281698
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000494 - box C/D sno(s)RNA 3'-end processing GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 321 Hs			1 582
+	Hs
		403085 FBRL_HUMAN (1-321): 1.98e-177: 495: 100.00		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		603482 FBRL_HUMAN (1-321): 1.98e-177: 495: 100.00		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		603568 FBRL_HUMAN (1-321): 1.98e-177: 495: 100.00		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		603691 FBRL_HUMAN (1-321): 1.98e-177: 495: 100.00		MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42
+	Hs
		603622 FBRL_HUMAN (1-321): 1.98e-177: 495: 100.00		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Hs
		603755 FBRL_HUMAN (1-321): 1.98e-177: 495: 100.00		RBM28_HUMAN (40-343): 2.97e-23: 106: 13.84
+	Hs
		603562 FBRL_HUMAN (1-321): 1.98e-177: 495: 100.00		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23