HitPredict

Interactor 1: FBRL (P22087)
rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (34 kDa nucleolar scleroderma antigen) (Histone-glutamine methyltransferase) (U6 snRNA 2'-O-methyltransferase fibrillarin)
Gene: FBL

Interactor 2: WDR36 (Q8NI36)
WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP)
Gene: WDR36

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

Property	Details
Experiments	26186194, 28514442, 29568061, 34079125, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0006364 - rRNA processing GO:0032040 - small-subunit processome GO:0042274 - ribosomal small subunit biogenesis
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 321 Hs			1 951
+	Sc
		549499 FBRL_YEAST (85-313): 1.1e-136: 392: 70.76		UTP21_YEAST (57-949): 1.79e-127: 410: 29.48
+	Hs
		603471 FBRL_HUMAN (1-321): 1.98e-177: 495: 100.00		TBL3_HUMAN (2-361): 3.23e-60: 222: 14.88
+	Hs
		603789 FBRL_HUMAN (1-321): 1.98e-177: 495: 100.00		WDR3_HUMAN (379-700): 3.49e-29: 127: 12.06
+	Hs
		603422 FBRL_HUMAN (1-321): 1.98e-177: 495: 100.00		WDR5_HUMAN (32-232): 5.32e-20: 94.4: 17.89
+	Sc
		549498 FBRL_YEAST (85-313): 1.1e-136: 392: 70.76		UTP13_YEAST (144-695): 3.95e-50: 192: 17.28
+	Sc
		549530 FBRL_YEAST (85-313): 1.1e-136: 392: 70.76		UTP12_YEAST (33-155): 4.19e-12: 72.3: 6.30
+	Ca
		1124180 Q5A0V9_CANAL (85-313): 1.82e-134: 386: 70.76		Q5A756_CANAL (4-151): 6.39e-09: 62.3: 5.92